A pilot study on the allergen-specific IgE to molecular components on polysensitized mite allergic asthmatic patients in Guangzhou, China

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Abstract

The objective of the study was to investigate the allergen sensitization profile of allergic asthma patients in southern China with the help of multiplex microarray-based component resolved diagnosis (CRD).

Blood serum samples from 57 polysensitized mite allergic asthmatic patients in a tertiary referral center of southern China were tested with multiplex CRD (ISAC) for specific immunoglobulin E (sIgE) against 112 single allergen and components.

Results: Patients with combined asthma and rhinitis (AA + AR) were sensitive to more components than those with asthma only (AA).

Conclusion: Being the first multiplex microarray-based CRD study on southern Chinese, ISAC showed house dust mites components were the major allergen components that led to sensitization in asthmatic patients. Patients with combined asthma and rhinitis were sensitive to more components than those with asthma only. Other components with a higher positive rate include pollen components nCyn d 1, nPhl P 4 and animal dander components rFel d 1 and rCan f 1. For B. tropicalis, the rBlo t 5 in ISAC may not represent the major Blomia component in southern Chinese patients.

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