Science Diabetes ulcers treatment

Abstract Omega-3-rich fish skin grafts have been shown to accelerate wound healing in full-thickness wounds.The goal of this study was to compare the fish skin graft with standard of care (SOC) using collagen alginate dressing in the management of treatment-resistant diabetic foot ulcers (DFUs), defined as superficial ulcers not involving tendon capsule or bone. Patients […]

Abstract Infected diabetic wounds are difficult to heal due to high reactive oxygen species (ROS) concentrations and recurrent infections.  Reactive oxygen species (ROS) serve as cell signaling molecules for normal biologic processes. However, the generation of ROS can also provoke damage to multiple cellular organelles and processes, which can ultimately disrupt normal physiology. Such wounds […]

Abstract in English, Chinese Diabetic wound is a common complication of diabetes, and the effect of current treatment is still poor. Curcumin has many pharmacological effects, such as anti-inflammatory, anti-oxidation, antimicrobial, anti-cancer, and improving insulin resistance. Conclusion: Curcumin can be used as a co-treatment in diabetic wound healing in combination with regular treatment.

Abstract Conservative surgery of diabetic foot osteomyelitis (DFO) in which bone infection is removed without amputation could minimize the biomechanical changes associated with foot surgery. We hypothesize that patients who undergo conservative surgery will have a longer survival time without recurrence of foot ulcers and further amputations than those who undergo any type of amputation […]

Abstract This study aimed to determine the prevalence of onychomycosis and interdigital tinea pedis in a cohort of Spanish patients with diabetes in whom onychomycosis was clinically suspected (n = 101). Samples from a first toenail scraping and the fourth toe clefts were subjected to potassium hydroxide direct vision and incubated in Sabouraud and dermatophyte […]

Abstract The anti-aging gene, klotho, has been identified as a multi-functional humoral factor and is implicated in multiple biological processes. However, the effects of klotho on podocyte injury in diabetic nephropathy are poorly understood. Thus, the current study aims to investigate the renoprotective effects of klotho against podocyte injury in diabetic nephropathy. We examined lipid […]

Abstract Extracellular vesicles from mesenchymal stromal cells (MSC-EVs) have shown promise in wound healing.  Extracellular vesicles are lipid bilayer-delimited particles that are naturally released from a cell and, unlike a cell, cannot replicate.  Extracellular vesicles range in diameter from near the size of the smallest physically possible unilamellar liposome (around 20-30 nanometers) to as large […]

Abstract Glomerular podocyte damage is considered to be one of the main mechanisms leading to Diabetic nephropathy. However, the relevant mechanism of podocyte injury is not yet clear. This study aimed to investigate the effect of peroxiredoxin 6 (Prdx6) on the pathogenesis of podocyte(kidney cells) injury induced by high glucose (HG). As a result, cells […]

Abstract Mangiferin is a prominent active component that can be derived from several traditional herbs, including Mangifera indica L., Anemarrhena asphodeloides Bge., and Belamcanda chinensis (L.) DC., which displays antidiabetic properties. Diabetic retinopathy (DR), a serious complication caused by diabetes, is the leading cause of blindness. The present study aimed to evaluate the beneficial effects […]

Abstract Diabetes mellitus (DM)-associated impairments in wound healing include prolonged inflammation, the overexpression of matrix metalloproteases (MMPs), and low levels of growth factors at the wound site. A metalloproteinase, or metalloprotease, is any protease enzyme whose catalytic mechanism involves a metal, which are involved in the crucial processes in the cells. The treatment with metalloprotease […]