Science Irritable bowel syndrome (IBS)

Main idea: Despite small effect sizes, eluxadoline demonstrated consistent and sustained improvement in WAP compared to placebo across a range of prospective and post hoc analyses. Assessing WAP response across a range of measures is important for fully understanding a treatment’s efficacy. Abstract Recurring abdominal pain is a characteristic and often unpredictable and debilitating symptom […]

Main idea: A significantly increased risk of osteoporosis among IBS patients was observed in this study. Early intervention to prevent the development of osteoporosis, such as weight-bearing exercise, adequate intake of vitamin D and calcium, and early screening for osteoporosis, may be beneficial for these patients, although further studies are still required to confirm the […]

Main idea: MBCT-IBS has the potential to reduce IBS symptoms and increase the quality of life. MBCT-IBS may exert its effect on IBS symptoms via reducing maladaptive illness conditions and activating changes in self-processing (reducing biases in self-referent processing of illness and health and increasing non-judgmental awareness). Abstract Irritable bowel syndrome (IBS) is a chronic […]

Main idea: This pilot study demonstrates the feasibility/acceptability of brief behavioral therapy for patients with IBS and poor sleep. Additionally, this study provides preliminary evidence to suggest that treatment of sleep difficulties in patients with IBS may improve IBS symptom outcomes. Abstract Up to 60% of patients with irritable bowel syndrome (IBS) report fatigue and […]

Main idea: This study shows that B bifidum HI-MIMBb75 substantially alleviates IBS and its symptoms in a real-life setting. These results indicate that specific beneficial bacterial effects are mediated independently of cell viability. Abstract Bifidobacterium bifidum MIMBb75 is one of a few probiotic strains that have been shown to be effective in the treatment of […]

Main idea: L. paracasei and B. longum may reduce GI symptom severity and improve the psychological well-being of individuals with certain IBS subtypes. Abstract Specific probiotic strains can alleviate the gastrointestinal (GI) symptoms and psychiatric comorbidities of irritable bowel syndrome (IBS). In this randomized double-blind placebo-controlled study the efficacy of Lactobacillus paracasei HA-196 (L. paracasei) […]

Main idea: FMT provided only transient relief of symptoms, although it induced a sustained alteration in the microbiota of IBS patients. Therefore, FMT delivered by a single infusion via colonoscopy can not be recommended as a treatment for IBS in clinical practice. Abstract Irritable bowel syndrome (IBS) has been associated with microbial dysbiosis. The aim […]

Main idea: Generally, probiotics may be safe and may improve whole gut transit time, stool frequency, and stool consistency. However, adequately powered RCTs are required to better determine the species or strains, doses, and duration of use of probiotics that are most efficacious. Further research and evidence are required before probiotics are adopted as one […]

Main idea: Linaclotide prolongs afferent gut-brain signaling from baseline but both afferent and efferent signaling were unaffected compared to placebo. Linaclotide significantly improves rectal hypersensitivity, IBS-C symptoms, and QOL compared to placebo. Abstract Linaclotide, a guanylate cyclase C agonist relieves irritable bowel syndrome with predominant constipation (IBS-C) symptoms. However, the pain-relieving properties are still unknown. […]

Main idea: The LFD combined with B-GOS prebiotic produced a greater symptom response than the sham diet plus placebo, but the addition of 1.4 g/d B-GOS did not prevent the reduction of bifidobacteria. The LFD reduces fecal Actinobacteria and butyrate thus strict long-term use should not be advised. Abstract The low FODMAP diet (LFD) reduces […]