Science Parkinson’s disease

Main idea: The recent study analyses several Chinese herbal treatments against Parkinson’s disease: Radix Paeoniae Rubra-Shu Dihuang-Gastrodia. The most beneficial combination was Radix Paeoniae Rubra-Shu Dihuang-Roasted Licorice. Roasted Radix Glycyrrhiza demonstrated a unique effect. Abstract  To systematically evaluate the efficacy of traditional Chinese medicine(TCM) compounds combined with levodopa medicine in the treatment of Parkinson’s disease. […]

Main idea: Tilavonemab (ABBV-8E12) is a monoclonal antibody that is supposed to be a potential treatment in neurodegenerative diseases. It works against tau protein, one of the crucial effectors in neurodegeneration. The recent study proves the lack of efficiency of tilavonemab in cases of neurodegenerative processes. Abstract  Progressive supranuclear palsy is a neurodegenerative disorder associated […]

Main idea:  Lipid-protein co-aggregation leads to changes in composition, molecular organization, morphology, lipid molecular dynamics, and surface properties of amyloid fibrils. It may also influence the association of amyloid fibrils with other molecules and assemblies, for example, cell membranes. α-syclein might remodel membranes and form co-aggregates with membrane lipids. Protein-lipid co-aggregates will have distinct physicochemical […]

Main idea: the recent study proves a connection between type 2 diabetes and Parkinson’s disease progression on genetic and behavioral levels. Abstract Type 2 diabetes (T2DM) and Parkinson’s disease (PD) are prevalent diseases that affect an aging population. Previous systematic reviews and meta-analyses have explored the relationship between diabetes and the risk of PD, but […]

Main idea: Focused ultrasound subthalamotomy treatment improved neuromotor function of Parkinson’s disease in selected patients with asymmetric signs. But such a treatment also had adverse events, such as speech and gait disturbances, weakness on the treated side, and dyskinesia. Abstract  The subthalamic nucleus is the preferred neurosurgical target for deep-brain stimulation to treat cardinal motor […]

Main idea: certain genetic polymorphisms of DRD3, such as rs76126170, rs9868039, and rs9817063 are connected to Parkinson’s disease susceptibility and also high efficiency of piribedil treatment. Abstract To investigate the correlation between the Dopamine D3 receptor (DRD3) 3’untranslated region (3’UTR) gene polymorphism and susceptibility to Parkinson’s disease (PD) and the clinical effect of the DRD2 […]

Main idea: the recent study proved that Parkinson’s disease affects the respiratory system through the neuromuscular system. The patients have impaired respiratory capacities that are related to the Parkinson’s disease severity, which can be used in diagnostics and respiratory conditions treatment. Abstract  Parkinson’s disease affects the neuromuscular system producing a loss of muscle strength that […]

Main idea: plasma levels of amyloid-beta 42 (Aβ42), Aβ40, total Tau, p-Tau181 are predictive markers of Alzheimer’s disease and Parkinson’s disease. Abstract  Easily accessible biomarkers for Alzheimer’s disease and related neurodegenerative disorders are urgently needed. In this study, we aimed to develop machine learning algorithms using multiplex blood-based biomarkers. Plasma samples were obtained from healthy […]

Main idea: Sevoflurane is a sweet-smelling, nonflammable, highly fluorinated methyl isopropyl ether used as an inhalational anesthetic. A recent study demonstrated that patients with Parkinson’s disease require a smaller concentration of sevoflurane compared to patients without Parkinson’s disease.  Clinicians should avoid an overdose of sevoflurane in patients with Parkinson’s disease. Abstract  An increasing number of […]

Main idea: Patients with Parkinson’s disease can be diagnosed through posture sway which makes diagnostics easier. Abstract  The severity of Parkinson’s disease (PD) is difficult to assess objectively owing to the lack of a robust biological marker of underlying disease status. The current standard tool is the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS). Postural sway […]