Currently, the 3 major groups of drugs used to manage obesity are as follows:
- Centrally acting medications that impair dietary intake;
- Medications that act peripherally to impair dietary absorption;
- Medications that increase energy expenditure.
Setmelanotide is the first drug approved for weight management in patients with rare genetic conditions (proopiomelanocortin [POMC], proprotein convertase subtilisin/kexin type 1 [PCSK1], leptin receptor [LEPR] deficiencies).
Two glucagon-like peptide-1 (GLP-1) agonists (liraglutide, semaglutide) have been approved by the US Food and Drug Administration (FDA) for chronic weight management.
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