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Aging

December 17, 2021
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The Effects of Caloric Restriction on Stem Cells
By AGE2B team
Reducing calories was shown to combat stem cell exhaustion in multiple ways. A review published in The Malaysian Journal of Medical Sciences has outlined what effects caloric restriction (CR) has on the development and differentiation of stem cells. Stem cells and their exhaustion The reviewers began by discussing stem cell exhaustion, a hallmark of aging and […]
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December 17, 2021
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Study Suggests No Theoretical Limit on Human Lifespan
By AGE2B team
This study does not refer to future rejuvenation biotechnology. According to new research, it may be possible for humans to live 130 years or perhaps longer, but the chances of reaching that age are slim. New findings suggest that mortality risk plateaus past 110 For many years now, just how long a human being can live […]
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December 17, 2021
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Understanding How We Evolved to Age
By AGE2B team
This paper provides a new, evolutionary look at the hallmarks of aging. In a paper in Frontiers in Genetics, Maël Lemoine of France’s CNRS offers an evolutionary perspective on the hallmarks of aging [1]. This review examines the appearance of the hallmarks in different groups across the tree of life, with the aim of providing a comprehensive picture […]
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December 17, 2021
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Matching an Epigenetic Clock to Physical Function
By AGE2B team
Physical function is itself a measurement of biological aging. A new, three-year study published in The Journals of Gerontology: Series A examined the relationship between epigenetic clocks and physical performance in older women. Epigenetic clocks and biological age  Epigenetic clocks attempt to estimate age based on measurable DNA modifications. However, not every individual ages at the same rate; […]
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December 17, 2021
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DNA Damage, Inflammation, and the Stem Cell Microenvironment
By AGE2B team
DNA damage harms both stem cells directly and the microenvironment in which they sit. A review published in Frontiers in Cell and Developmental Biology has explained how DNA damage and its accompanying immune response lead to changes in the microenvironment of stem cells, causing a decline in their function. A direct relationship After an introduction, the reviewers begin […]
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December 17, 2021
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A Cause of Genomic Instability Discovered
By AGE2B team
Researchers have discovered a reason why our DNA is not being repaired as we age. Research further illuminating the mechanisms of impaired DNA damage repair associated with aging has recently been published in the journal Aging. DNA damage repair is reduced as we age  While we have multiple mechanisms for repairing genomic damage, one type […]
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December 17, 2021
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The Genetic Basis of Telomere Length
By AGE2B team
This human study eludicates the relationship between genes and telomeres. A new study in Nature Genetics has further illuminated the genetic regulation of telomere length and what implications it may have for various diseases and longevity. At one time the hottest topic in aging, telomeres are the protective caps at the ends of our DNA. They are truncated […]
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December 17, 2021
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Why we age: Altered Intercellular Communication
By AGE2B team
Altered intercellular communication, as described in the Hallmarks of Aging [1], is the change in signals between cells that can lead to some of the diseases and disabilities of aging. It is also one of the nine reasons we age. Inflammation and hormonal imbalance As we age, the signaling environment of chemical messages across the whole body tends […]
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December 17, 2021
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Why we age: Loss of Proteostasis
By AGE2B team
The loss of proteostasis is one of the reasons we age. The Hallmarks of Aging [1] describes the loss of proteostasis as the failure of the protein building machinery of the cell and the accumulation of misfolded proteins, which is one of the root causes of age-related diseases, including Alzheimer’s disease. What are proteins? Proteins are large, complex […]
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December 17, 2021
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Why we age: Mitochondrial Dysfunction
By AGE2B team
Mitochondrial dysfunction is one of the root causes of aging as described in the Hallmarks of Aging [1]. As they age, mitochondria lose their ability to provide cellular energy and release reactive oxygen species that harm cells. What are mitochondria? Mitochondria, which are often called the powerhouses of cells, act like miniature factories, converting the food we […]
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