Main idea: In this proof-of-concept trial intralymphatic immunotherapy was well tolerated and improved the symptoms and medication use associated with allergic rhinoconjunctivitis caused by mountain cedar pollen.
Abstract
Allergen immunotherapy can provide long-term benefits, including symptomatic relief and reduced disease progression, but it requires a prolonged regimen that presents barriers to patient adherence. Thus, there is a need for improved approaches to immunotherapy. Recently, several clinical trials have reported successful results from intralymphatic immunotherapy.
The objective of the study was to evaluate the efficacy, safety, and tolerability of intralymphatic immunotherapy for allergies caused by mountain cedar pollen in a proof-of-concept study.
A total of 21 patients with allergic rhinoconjunctivitis because of mountain cedar pollen were randomized to receive 3 monthly intralymphatic injections of allergenic extract or placebo before the 2018-2019 mountain cedar pollen season.
Results: There were no serious adverse events or systemic reactions in either group. A total of 4 patients experienced mild injection-site reactions. Patients receiving intralymphatic immunotherapy experienced a significant improvement in allergy symptoms and medication use relative to patients receiving placebo. Moreover, the active treatment group had a lower average total combined scores on 20 out of 27 days during the peak pollen season. There was no significant difference among groups in changes to mean mountain cedar-specific serum immunoglobulin E levels.
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