Long-term follow-up of efficacy of insulin pump in the treatment of children with type 1 diabetes mellitus

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Abstract

The objective of the study wasto examine the clinical effect of continuous subcutaneous insulin infusion versus multiple daily injections (MDI) on blood glucose control in children with type 1 diabetes mellitus (T1DM).

A retrospective analysis was performed on the medical data of 91 children with T1DM who were treated with continuous subcutaneous insulin infusion for more than 1 year and 75 children with T1DM who were treated with MDI. The two groups were compared in terms of glycosylated Hemoglobin A1c(HbA1c) (Hemoglobin A1c(HbA1c)e A1c(HbA1c)) and the recurrence of diabetic ketoacidosis (DKA) to evaluate the difference in the efficacy during the 3-year follow-up. A survey was conducted for the children in the continuous subcutaneous insulin infusion group and their family members to investigate the degree of satisfaction with the insulin pump.

Results: There was no significant difference in age, sex, and course of diabetes between the continuous subcutaneous insulin infusion and MDI groups at disease onset and in the first year, the second year, and the third year of follow-up. There was no significant difference in the Hemoglobin A1c(HbA1c)e A1c(HbA1c)(hemoglobin) level between the two groups at the disease onset, but in the first year of follow-up, the continuous subcutaneous insulin infusion group had a significantly lower Hemoglobin A1c(HbA1c)e A1c(HbA1c)(hemoglobin)  level than the MDI group. There was no significant difference in the Hemoglobin A1c(HbA1c)e A1c(HbA1c) levels between the two groups in the second year and the third year of follow-up.

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