Gout and Progression of Aortic Stenosis

Andrew Adelsheimer 1, Binita Shah 2, Alana Choy-Shan 3, Craig T Tenner 4, Jeffrey D Lorin 3, Nathaniel R Smilowitz 3, V Courtney Pike 5, Michael H Pillinger 5, Robert Donnino 3

Main idea: Progression to severe aortic stenosis was more frequent in patients with gout compared with those without gout, supporting the hypothesis that gout is a risk factor for aortic stenosis.

Abstract

Background: Patients with aortic stenosis are nearly twice as likely to have a diagnosis of gout compared with individuals without aortic valve disease.

Methods: This retrospective study evaluated consecutive adults age 65 years with aortic stenosis between December 2012 and November 2016 who underwent at least 2 transthoracic echocardiograms separated by at least 1 year. Severe aorto-venous stenosis was defined as a decrease in left ventricular ejection fraction.

Results: Of the 699 study patients, gout was present in 73 patients (10%) and not found in 626 patients (90%) Median follow-up was 903 days for patients with gout and 915 days for patients without gout. The presence of severe aortic stenosis on following- up transthoracic echocardiogram was more frequent in patients with Gout compared to those without. Gout remained associated with the development of severe stenosis after multivariable adjustment after adjustment for adjusted hazard ratio.

Source NIH