Asymptomatic hyperuricemia and incident congestive heart failure in elderly patients without comorbidities

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Xianfeng Wu 1, Guihua Jian 1, Yuezhong Tang 2, Huan Cheng 2, Niansong Wang 3, Junnan Wu 4

Main idea: Asymptomatic hyperuricemia was a valuable biomarker for predicting the development of incident CHF (chronic heart failure) in elderly patients without comorbidities.

Abstract

Background and aims: Although hyperuricemia is associated with congestive heart failure (CHF), hyperuricemic patients frequently have other comorbidities. Thus, it is difficult to distinguish the role of hyperuricemia from that of other comorbid conditions in CHF. The aim of this study was to evaluate the association between hyperuricemia and CHF in elderly patients without comorbidities.

Methods and results: Asymptomatic hyperuricemia was associated with an increased cumulative incidence of incident CHF events. A total of 2749 subjects (70.9± 6.0 years) were followed for 47.4± 3.6 months. After adjusting for confounding factors, including baseline eGFR, hyperuricemia independently predicted the risk of incident CHF events, and CHF rates were 6.5% versus 3.1% for normoglycemic subjects. The study was conducted at the Kangjian Community Health Center of Shanghai.

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