Science Mood disorders microbiome

Main idea: Complex treatment of selective serotonin reuptake inhibitor with probiotic bacteria LP299v  improved cognitive performance and decreased inflammatory markers concentration in mood disorder patients. Decreased kynurenine concentration could contribute to the improvement of cognitive functions in the LP299v group compared to the placebo group. To our knowledge results of this study are the first […]

Abstract There has been an increased interest in understanding the therapeutic effect of gut-microbiota on health, particularly in mental health. Limited research into the connection between gut microbiota and mental health makes this study an important endeavor. Eligible participants completed a baseline survey before being assigned to a condition, which consisted of four probiotics conditions […]

Main idea: There’s novel interventional evidence that alteration in the microbiome due to flavonoid treatment (in orange juice) is related to a potential improvement in depression in young adults. Abstract Depression is not just a general mental health problem but a serious medical illness that can worsen without treatment. The gut microbiome plays a major role […]

Main idea: Gut microbiota plays an important role in anorexia nervosa and especially focuses on the therapeutic potential of fermented foods, proposed here as a recommended addition to the current nutritional treatment protocols warranting further investigation. Abstract Anorexia nervosa is a serious psychiatric disorder with high morbidity and mortality rate. Treatment focuses on weight restoration through […]

Main idea: Unpredictable chronic mild stress, diet, and gut microbiota generate a pathological feed-forward loop that contributes to despair behavior via the central endocannabinoid system. Abstract Depression is the leading cause of disability worldwide. Recent observations have revealed an association between mood disorders and alterations of the intestinal microbiota. In a mouse model of depression, mice […]

Main idea: Intermittent fasting is one measure that can control gestational diabetes mellitus and maternal mood dysregulations. Abstract Gestational diabetes mellitus (GDM) is a common pregnancy-related condition afflicting 5-36% of pregnancies. It is associated with many morbid maternal and fetal outcomes. Maternal hyperglycemia and mood dysregulations result from a complex network of genetic, behavioral, and environmental […]

Main idea: gut microbiome regulates the work of gastrointestinal glial cells (part of the neural system) and plays a crucial part in mood disorders formation. Abstract The immune-inflammatory response is a fundamental component of the pathophysiology of major depressive disorder (MDD) Psychological stress and various inflammatory conditions contribute to such immune activation. The gastrointestinal tract, intestinal […]

Main idea: Although the clinical and preclinical studies are sparse and not very consistent, they suggest that sex differences in the gut microbiota may play an essential role in some neuropsychiatric conditions. Abstract Sex differences are often observed in psychiatric patients. The microbiota-gut-brain axis hypothesis arises to explain some aspects of the complex pathophysiology of neuropsychiatric […]

Main idea: indole production by the gut microbiota may play a role in the onset of mood disorders in humans, urinary excretion of 3-indoxyl sulfate can be a marker for indole production. Abstract Gut microbiota metabolizes tryptophan(an essential amino acid) into indole, which can influence the brain and behavior. Some oxidized derivatives of indole have neuroactive […]

Main idea: gut microbiome can eliminate stress effects in mood disorders formation. Abstract Episodes of depression and anxiety commonly follow the experience of stress, however, not everyone who experiences stress develops a mood disorder. Stress alters the gut microbiota and plausibly this could contribute to stress-related changes in mood. Stress-resilience is influenced by several psychological and […]