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Researchers have discovered a novel and druggable insulin inhibitory receptor, named inceptor. In experiments with mice, the researchers showed that the function of inceptor is to shield the insulin-producing beta cells from constitutive insulin pathway activation. The blocking of inceptor function leads to an increased availability of the insulin signaling pathway in pancreatic beta cells. […]

The researchers evaluated the walking patterns and brain function of 500 participants currently enrolled in clinical trials and found how walking pattern changes in neurodegenerative conditions, like Alzheimer’s disease and dementia. The recent study compared gait impairments across the cognitive spectrum, including people with Subjective Cognitive Impairment, Parkinson’s Disease, Mild Cognitive Impairment, Alzheimer’s disease, Lewy […]

Early identification of pre-ulcerative pathology is important to preventing diabetic foot ulcers (DFU), but signs of inflammation are difficult to detect on the feet of patients with diabetic neuropathy due to decreased sensation. In the recent study scientists from Tokyo created a self-monitoring device that can detect DFU when attached to a smartphone. One of […]

Dogs like humans demonstrate decline in cognitive abilities (up to deficits) and behavior changes with age. Thus, dogs need help and correction for these disorders. Some studies suggest that training programs and a nutrient-rich diet slow down the aging process and cognitive and behavioral changes. In the recent study the animals ate either an enriched […]

The researchers from the University of Missouri School of Medicine and MU Health Care compared four drugs with different mechanisms of action in a large group of patients with cryptogenic sensory polyneuropathy (CSPN) to determine which drugs are most useful for this condition. The clinical study involved 40 sites and enrolled 402 patients with diagnosed […]

Intensive interventions to reduce blood glucose and blood pressure levels in type 2 diabetes reduce the risk of developing cardiovascular autonomic neuropathy (CAN), a frequent but underdiagnosed complication of diabetes that can be life-threatening. In the recent study researchers found that intensive glycemic control reduced CAN risk by 17%, while intensive blood pressure control reduced […]

Our researchers and editors are still working on this article. We’ll appreciate it if you share with us any thoughts or concerns (especially if you found a typo or something you disagree with). We’ll publish the most important comments on your blog. Mitochondria are dynamic organelles responsible for energy production inside cells. Dysfunction of mitochondria […]