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Researchers from Skoltech and the University of Texas at Austin have presented a proof of concept for a wearable sensor that can track healing of chronic skin wounds, even without the need to remove the bandages. The team used a simulated wound environment to test the sensitivity of their sensor to three critical biomarkers: pyocyanin, […]

A team of researchers from Russia, the Czech Republic and Israel has found that the reason some blind mole rats live longer than other small creatures is because they have short immune memory With age, they do not accumulate large populations of long-lived memory cells; this allows to preserve the diversity of naive T cells […]

Semaglutide is clinically approved to be used for patients with type 2 diabetes, though is typically prescribed in much lower doses of 1mg. In the recent study the drug has been used in obesity treatment. The drug, semaglutide, works by hijacking the body’s own appetite regulating system in the brain leading to reduced hunger and […]

Increasing insulin sensitivity is a cornerstone of diabetes treatment and prevention. Unfortunately, not all patients succeed in consistently adhering to their doctors recommendations, and millions have serious complications, leading, among other things, to renal failure, blindness and amputation of limbs due to damage to blood vessels and nerves. In the recent study the scientists improved […]

Researchers have discovered the barrier to β-cell regeneration that could pave the way for improved treatments for diabetes and diseases that involve organ and tissue damage. This process is regulated by methylation changes of two key developmental genes Ngn3 and Sox 11. They have been known before, the recent study demonstrated how exactly regulation of […]

Researchers have discovered a novel and druggable insulin inhibitory receptor, named inceptor. In experiments with mice, the researchers showed that the function of inceptor is to shield the insulin-producing beta cells from constitutive insulin pathway activation. The blocking of inceptor function leads to an increased availability of the insulin signaling pathway in pancreatic beta cells. […]

The researchers evaluated the walking patterns and brain function of 500 participants currently enrolled in clinical trials and found how walking pattern changes in neurodegenerative conditions, like Alzheimer’s disease and dementia. The recent study compared gait impairments across the cognitive spectrum, including people with Subjective Cognitive Impairment, Parkinson’s Disease, Mild Cognitive Impairment, Alzheimer’s disease, Lewy […]

Early identification of pre-ulcerative pathology is important to preventing diabetic foot ulcers (DFU), but signs of inflammation are difficult to detect on the feet of patients with diabetic neuropathy due to decreased sensation. In the recent study scientists from Tokyo created a self-monitoring device that can detect DFU when attached to a smartphone. One of […]

Dogs like humans demonstrate decline in cognitive abilities (up to deficits) and behavior changes with age. Thus, dogs need help and correction for these disorders. Some studies suggest that training programs and a nutrient-rich diet slow down the aging process and cognitive and behavioral changes. In the recent study the animals ate either an enriched […]

The researchers from the University of Missouri School of Medicine and MU Health Care compared four drugs with different mechanisms of action in a large group of patients with cryptogenic sensory polyneuropathy (CSPN) to determine which drugs are most useful for this condition. The clinical study involved 40 sites and enrolled 402 patients with diagnosed […]