Dysregulation of the gut-brain-skin axis and key overlapping inflammatory and immune mechanisms of psoriasis and depression

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Main idea: psoriasis is connected to gut microbiome disbalance.

Abstract

The occurrence, progression, and recurrence of psoriasis are thought to be related to mood and psychological disorders such as depression. Psoriasis can lead to depression, and depression, in turn, exacerbates psoriasis. The gut-brain-skin axis has been used to explain correlations among the gut microbiota, emotional states, and systemic and skin inflammation. This axis may be associated with overlapping mechanisms between Psoriasis and depression. No specific mechanism can explain the association between psoriasis and depression.

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