Early-onset type 2 diabetes: A high-risk factor for proliferative diabetic retinopathy (PDR) in patients with microalbuminuria

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Xinlu Lv 1, Xi Ran 2, Xiangjun Chen 1, Ting Luo 1, Jinbo Hu 1, Yue Wang 1, Zhiping Liu 1, Qianna Zhen 1, Xiurong Liu 1, Li Zheng 1, Ying Tang 1, Qinying Zhao 1, Shichao Han 3, Yangmei Zhou 1, Wenjin Luo 1, Lina Yang 1, Qifu Li 1, Zhihong Wang 1

Main idea: In T2DM patients with microalbuminuria, early-onset diabetes is an independent risk factor for the development ofproliferative diabetic retinopathy.

Abstract

A total of 461 T2DM patients with microalbuminuria were enrolled. PDR was defined as the presence of any of the following changes on fundus photography: neovascularization, vitreous hemorrhage, or preretinal hemorrhage. Prevalence of PDR 6-fold higher in patients with early-onset diabetes than late-onsets. Early-onsET diabetes, use of oral hypoglycemic drugs, and insulin therapy were risk factors for PDR, but sex, duration of diabetes, insulin therapy, and use of other drugs played a role as well. 

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