Effects of Non-Drug Interventions on Depression, Anxiety and Sleep in COVID-19 Patients: A Systematic Review and Meta-Analysis

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Main idea: This meta-analysis found that non-drug interventions can reduce the anxiety and depression scores of patients with COVID-19. Due to the limitations of this study, more high-quality studies are needed to verify the findings, especially the effect of non-drug interventions on improving the sleep status of COVID-19 patients.

Abstract

Objective: Patients with Coronavirus Disease 2019 (COVID-19) suffer from anxiety, depression, and sleep disorders due to isolation treatment, among other reasons. Whether non-drug interventions can be alternative therapies for COVID-19 patients with anxiety, depression, and sleep disorders is controversial. Therefore, a meta-analysis and systematic review were conducted to evaluate the effects of non-drug interventions on anxiety, depression, and sleep disorders in patients with COVID-19 to provide guidance for clinical application.

The following databases for randomized controlled trials (RCTs) from December 2019 to July 2020 were analyzed: China Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Chongqing VIP Chinese Science and Technology Periodical Database (VIP), Wanfang, Cochrane Library, Web of Science, PubMed, MEDLINE and Embase.

Results: A total of 5 articles with 768 subjects were included. Meta-analysis results indicated that non-drug interventions can reduce anxiety and depression scores in patients with COVID-19. Descriptive analysis indicated that non-drug interventions can improve the sleep status of COVID-19 patients. Sensitivity analysis indicated that the meta-analysis results were stable. Egger’s test and Begg’s test showed no publication bias.

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