Effects of Propranolol in Accelerating Wound Healing and Attenuation of Hypermetabolism in Adult Burn Patients

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Saeed Ashraf Cheema 1, Urwa Tanveer Ahmed 1, Hafsa Nasir 1, Shumaila Rehman Dogar 1, Zunaisra Mustafa

Main idea: Propranolol administration in adult burn patients appears to be beneficial in reducing morbidity, mortality and hospital stay by enhancing earlier wound healing and attenuating the catabolic muscle wasting in response to stress caused by burn.

Abstract

Objective: To compare the mean duration of wound healing and attenuation of muscle wasting in adult burn patients treated with propranolol and control group.

Methodology: Seventy adult burn patients with 20-40% burn of the total body surface area (TBSA) were included in the study and divided into two groups; propranolol group and control group. Propranolol was administered at a dose of 0.5-3 mg/Kg body weight per day along with standard burn care treatment during the entire period of treatment.

Results: Faster healing of the superficial burns was noticed in the patients of the propranolol group. In superficial burns lesser time was needed for adequate healing. Less time was required for deep burns to be ready for skin grafting. This result showed that the hypermetabolic response of burn-in terms of muscle wasting was clearly modulated by beta-blocker therapy.

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