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Efficacy of a Novel Intranasal Formulation of Azelastine Hydrochloride and Fluticasone Propionate, Delivered in a Single Spray, for the Treatment of Seasonal Allergic Rhinitis: Results from Russia

By AGE2B team
November 7, 2021
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Main idea: MP-AzeFlu was superior to AZE in reducing moderate-to-severe seasonal allergic rhinitis symptoms, providing earlier and better symptom relief.

Abstract

The novel intranasal formulation of azelastine hydrochloride (AZE) and fluticasone propionate (FP) in a single spray (MP-AzeFlu) was compared with a first-line intranasal antihistamine spray (AZE) in Russian seasonal allergic rhinitis (SAR) patients.

Moderate-to-severe allergic rhinitis and rhinoconjunctivitis patients (n = 149; aged 18-65 years) were randomized to receive MP-AzeFlu (137/50 μg AZE/FP per spray) or AZE (137 μg/spray), both as 1 spray per nostril twice daily, in a multi-center, open-label, 14-day, parallel-group trial.

Results: When compared with AZE spray-treated patients, those treated with MP-AzeFlu experienced significantly greater reductions in rhinitis and conjunctivitis symptoms. Superior relief observed on day 2 with MP-AzeFlu versus AZE was sustained throughout the study. MP-AzeFlu-treated patients experienced a greater improvement in the quality of life than AZE-treated. MP-AzeFlu spray was well tolerated.

Source Karger

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