Impact of Microbial Metabolites on Microbiota-Gut-Brain Axis in Inflammatory Bowel Disease

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Main idea: The participation of the main microbial-derived metabolites, also defined as “postbiotics”, such as bile acids, short-chain fatty acids, and tryptophan metabolites in the development of IBD-associated gut and brain dysfunction will be discussed.

Abstract

The bidirectional communication system existing between the gastrointestinal tract and the brain has a fundamental role in the pathogenesis of Inflammatory Bowel Disease (IBD) Mood disorders and increased response to stress are frequently associated with IBD and may affect the disease recurrence and severity. This review highlights the more recent evidence suggesting that alterations of the microbiota-gut-brain bid Directional communication axis may concur to IBD pathogenesis and sustain the development of local and CNS symptoms.

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