Impact of type 2 diabetes mellitus on mid-term mortality for hypertrophic cardiomyopathy patients who underwent septal myectomy

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Shengwei Wang 1, Hao Cui 2, Keshan Ji 3, Changpeng Song 3, Changwei Ren 1, Hongchang Guo 1, Changsheng Zhu 4, Shuiyun Wang 5, Yongqiang Lai 6

Main idea: Hypertrophic cardiomyopathy patients with and without type 2 diabetes mellitus have similar 3-year cardiovascular mortality after septal myectomy. However, type 2 diabetes mellitus is associated with higher sudden cardiac death rate in these patients. In addition, N-terminal pro-brain natriuretic peptide and glomerular filtration rate ≤ 80 ml/min were independent risk factors among hypertrophic cardiomyopathy patients with type 2 diabetes mellitus.

Abstract

Background: Type 2 diabetes mellitus is common in cardiovascular disease. It is associated with adverse clinical outcomes for patients who had undergone coronary artery bypass and valve operations. The aim of this study was to evaluate the impact of type 2 diabetes mellitus on the midterm outcomes of patients with hypertrophic cardiomyopathy who underwent septal myectomy.

Methods: We retrospectively analyzed the data of 67 hypertrophic cardiomyopathy patients with type 2 diabetes mellitus who underwent septal myectomy from two medical centers in China from 2011 to 2018. A propensity score-matched cohort of 134 patients without type 2 diabetes mellitus was also analyzed. Results: During a median follow-up of 28.0 months, 9 patients died. Patients with type 2 diabetes mellitus had a higher rate of sudden cardiac death. Rates of predicted 3-year survival were significantly higher in hypertrophic cardiomyopathy patients without type 2 Diabetes mellitus than in those with Type 2 Diabetes Meningitis. After adjustment for age and sex, only N-terminal pro-brain natriuretic peptide and glomerular filtration rate were independent risk factors for hypertrophicCardiomyopathic patients with diabetes Mellitus. The study was published in the Journal of Cardiovascular Disease.

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