Improvement of gastrointestinal discomfort and inflammatory status by a synbiotic in middle-aged adults: a double-blind randomized placebo-controlled trial

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Main idea: This study demonstrates that a combination of Bifidobacterium animalis lactis and the well-known prebiotic FOS could be a promising synbiotic strategy to decrease inflammatory status with the improvement of gut disorders in middle-aged people.

Abstract

Several studies suggest that microbial alterations (dysbiosis) are intimately linked to chronic inflammation occurring upon aging. The aim of this study was to investigate the potential interest of a synbiotic approach (combination of probiotic bacteria and a prebiotic dietary fiber) to improve gastrointestinal wellness and inflammatory markers in middle-aged people.  Middle-aged subjects were taken synbiotic or placebo for 30 days. Stool frequency and consistency were improved in both placebo and synbiotics-treated volunteers. Plasma pro-inflammatory cytokines were significantly lower. This effect appears to be independent of the gut barrier function.

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