Improvement of gastrointestinal discomfort and inflammatory status by a synbiotic in middle-aged adults: a double-blind randomized placebo-controlled trial


Main idea: This study demonstrates that a combination of Bifidobacterium animalis lactis and the well-known prebiotic FOS could be a promising synbiotic strategy to decrease inflammatory status with the improvement of gut disorders in middle-aged people.


Several studies suggest that microbial alterations (dysbiosis) are intimately linked to chronic inflammation occurring upon aging. The aim of this study was to investigate the potential interest of a synbiotic approach (combination of probiotic bacteria and a prebiotic dietary fiber) to improve gastrointestinal wellness and inflammatory markers in middle-aged people.  Middle-aged subjects were taken synbiotic or placebo for 30 days. Stool frequency and consistency were improved in both placebo and synbiotics-treated volunteers. Plasma pro-inflammatory cytokines were significantly lower. This effect appears to be independent of the gut barrier function.


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