The differences in plasma/serum ghrelin levels between obstructive sleep apnea-hypopnea patients and controls: A protocol for systematic review and meta-analysis

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Main idea: Meta-analysis A demonstrated that plasma/serum ghrelin levels had no significant differences between the obstructive sleep apnea-hypopnea syndrome group and the control group. Meta-analysis B showed plasma/serum ghrelin levels had no significant changes after CPAP therapy in obstructive sleep apnea-hypopnea syndrome patients.

Abstract

Background: The association between obstructive sleep apnea-hypopnea syndrome (OSAHS) and plasma/serum ghrelin levels remains controversial. We performed a meta-analysis to evaluate the difference in plasma/serum ghrelin levels between OSAHS patients and controls.

Results: Meta-analysis A pooled the comparison of ghrelin concentrations in obstructive sleep apnea-hypopnea syndrome patients and controls, which included 7 studies and involving 446 participants. The result of meta-analysis A indicated that plasma/serum ghrelin levels had no significant differences between the OSAHS group and the control group (standard mean difference (SMD) = 0.08, 95% confidence interval). As a supplementary, meta-analysis B pooled the comparison of plasma/serum ghrelin levels in obstructive sleep apnea-hypopnea syndrome patients before and after continuous positive airway pressure (CPAP) therapy, which included 155 participants from 4 studies. It revealed that plasma/serum ghrelin levels had no significant differences between before and after CPAP therapy.

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