The effect of a hydrolyzed collagen-based supplement on wound healing in patients with burn: A randomized double-blind pilot clinical trial


Katayoun Bagheri Miyab 1, Elham Alipoor 2, Reza Vaghardoost 3, Mohsen Saberi Isfeedvajani 3, Mehdi Yaseri 4, Kurosh Djafarian 1, Mohammad Javad Hosseinzadeh-Attar

Main idea: The findings showed that a hydrolyzed collagen-based supplement could significantly improve wound healing and circulating prealbumin, and clinically reduce hospital stay in patients with 20-30% burn.


Introduction: Burn is among the most severe forms of critical illness, associated with extensive and prolonged physical, metabolic and mental disorders. The aim of this study was to assess the effect of an oral, low-cost, and accessible collagen-based supplement on wound healing in patients with burn.

Methods: In this randomized double-blind controlled pilot clinical trial, 31 men, 18-60years, with 20-30% total body surface area burn were studied. Patients were randomly assigned to receive either a collagen-based supplement (1000kcal) or an isocaloric placebo, for 4 weeks. Serum prealbumin, rate of wound healing, length of hospital stay, and anthropometries were assessed at baseline, and the end of week 2 and 4.

Results: Serum prealbumin was significantly higher at week 2 and week 4 than in the control group. The Hazard ratio of wound healing was 3.7 times in collagen compared to the control group. Hospital stay was clinically, but not statistically, lower in collagen than the control group. There were no significant differences in weight, body mass index, dietary energy, and protein intake.


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