Main idea: Vitamin D supplementation in patients with painful diabetic neuropathy reduced pain symptoms, enhanced neural connectivity without serious adverse effects.
Abstract: In this systematic review and meta-analysis, higher quality data evidence on vitamin D supplementation for painful diabetic neuropathy (PDN) will be provided. Vitamin D supplementation in patients with painful diabetic neuropathy reduced pain symptoms, enhanced neural connectivity without serious adverse effects. It is common for vitamin D deficiency in diabetic patients and especially in these patients diagnosed with diabetic peripheral neuropathy. Previous studies have proved that there is an apparent vitamin D deficiency in PDN patients, and vitamin D supplementation can effectively improve patients” pain symptoms and neurologic function. Painful diabetic neuropathy (PDN) is one of the main and severe complications of diabetic patients, which not only accelerates the occurrence of ulcers of diabetic foot and amputation of lower extremities but also severely affects the quality of life. The primary endpoint was the safety and tolerability of mirogabalin, evaluated via treatment-emergent adverse events (TEAEs). Secondary efficacy endpoints included change in ADPS from baseline to Week 14. However, the evidence of these studies is unconvincing.
Source MD-Journal
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