The Prevalence and Risk of Sleep Disorders in Patients With Functional Dyspepsia: A Meta-Analysis


Main idea: The meta-analysis has demonstrated that sleep disorders are often associated with functional dyspepsia and are observed in about every second patient with this functional gastrointestinal disease. Further research is needed to investigate possible causal relationships between sleep disorders and functional dyspepsia.


Systematization of data on the incidence and risk of sleep disorders in patients with functional dyspepsia (FD).

Results: The final analysis included 10 studies with 7739 people (2354 patients with FD, 5385 controls). The generalized incidence of sleep disturbances in patients with FD was 53.23% (95% CI: 37.738-68.419). There was significant heterogeneity between the results (p<0.0001; I2=98.05%). An association was found between FD and sleep disorders (OR 2.884; 95% CI 2.518-3.304; I2=28.35%) compared with controls. In patients with epigastric pain syndrome (EPS), the generalized incidence of sleep disorders was 40.6% (95% CI 34.267-47.181; I2=0%), with postprandial distress syndrome (PDS) – 51.82% (95% CI 26.479-76.666; I2=94.76%), and at the intersection of EPS and PDS – 51.67% (95% CI 23.497-79.270; I2=95.34%).


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