Wound healing effects of topical Vitamin K: A randomized controlled trial


Nader Pazyar 1, Gholamreza Houshmand 2, Reza Yaghoobi 1, Ali Asghar Hemmati 3, Zahra Zeineli 1 4, Behnam Ghorbanzadeh 5

Main idea: A randomized, controlled trial suggests that topical application of Vitamin K significantly reduces healing time in patients.


Background: The incidence of acute and chronic wounds has rapidly increased which treatment remains a health problem. Previously, we reported the healing effect of Vitamin K in experimental animal models. The aim of this study was to investigate the effects of topical Vitamin K on skin wound healing process in patients.

Materials and methods: Sixty-three patients with indication for high-frequency electrocautery were enrolled in this randomized controlled trial. The patients were divided randomly into three groups. All the patients underwent high-frequency electrocautery treatment. Then, the patients in the A group received 1% Vitamin K cream, the patients in the B group received 1% phenytoin cream. Furthermore, the patients in the control group received Eucerin. The wound status (width and the time of recovery) and complications in the three groups were evaluated 2 weeks after procedure by a dermatologist.

Results: The effects produced by the topical Vitamin K showed a significant healing when compared with Eucerin group in parameters such as wound contraction and time to full recovery. Moreover, the healing time did not differ between phenytoin and Vitamin K groups.


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