Currently set to Index
Currently set to Follow
ask age2b

Associations among Cognitive Functions, Plasma DNA, and Diffusion Tensor Image along with the Perivascular Space (DTI-ALPS) in Patients with Parkinson’s Disease

By AGE2B team
March 19, 2021

Main idea: Lower diffusivity along with the perivascular space, represented by lower ALPS-index, indicates impairment of the glymphatic system in PD patients. The correlation between elevated plasma nuclear DNA levels and lower ALPS-index supports the notion that PD patients may exhibit increased oxidative stress associated with glymphatic system microstructural alterations.


Parkinson’s disease (PD) is a common neurodegenerative disease associated with the accumulation of misfolded proteins and increased neuroinflammation. This study was to evaluate glymphatic system activity and its relationship with systemic oxidative stress status in PD patients. Magnetic resonance imaging and neuropsychological tests were conducted on PD patients. Oxidative stress status was assessed by plasma DNA level. Differences in ALPS-index among the subgroups were assessed and further correlated with cognitive functions. The PD-MCI and PDD groups showed significantly lower ALPS-index compared to normal controls. The ALPS-index was inversely correlated with plasma nuclear DNA, mitochondrial DNA levels, and cognitive scores.

Source Hindawi

Leave a Reply

Ask your question

We read all your emails and your text. Your question will be responded by our specialists, or one of the doctors we're working with, or our community

Please complete the required fields.