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Science Parkinson’s disease

Systematic review and screening of basic Chinese herbs for traditional Chinese medicine compounds combined with levodopa medicine in the treatment of Parkinson’s disease [Original in Chinese]
November 4, 2021
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Main idea: The recent study analyses several Chinese herbal treatments against Parkinson’s disease: Radix Paeoniae Rubra-Shu Dihuang-Gastrodia. The most beneficial combination was Radix Paeoniae Rubra-Shu Dihuang-Roasted Licorice. Roasted Radix Glycyrrhiza demonstrated a unique effect. Abstract  To systematically evaluate the efficacy of traditional Chinese medicine(TCM) compounds combined with levodopa medicine in the treatment of Parkinson’s disease. […]
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Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomized, placebo-controlled trial
November 4, 2021
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Main idea: Tilavonemab (ABBV-8E12) is a monoclonal antibody that is supposed to be a potential treatment in neurodegenerative diseases. It works against tau protein, one of the crucial effectors in neurodegeneration. The recent study proves the lack of efficiency of tilavonemab in cases of neurodegenerative processes. Abstract  Progressive supranuclear palsy is a neurodegenerative disorder associated […]
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Transient Lipid-Protein Structures and Selective Ganglioside Uptake During α-Synuclein-Lipid Co-aggregation
November 7, 2021
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Main idea:  Lipid-protein co-aggregation leads to changes in composition, molecular organization, morphology, lipid molecular dynamics, and surface properties of amyloid fibrils. It may also influence the association of amyloid fibrils with other molecules and assemblies, for example, cell membranes. α-syclein might remodel membranes and form co-aggregates with membrane lipids. Protein-lipid co-aggregates will have distinct physicochemical […]
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Type 2 Diabetes as a Determinant of Parkinson’s Disease Risk and Progression
November 7, 2021
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Main idea: the recent study proves a connection between type 2 diabetes and Parkinson’s disease progression on genetic and behavioral levels. Abstract Type 2 diabetes (T2DM) and Parkinson’s disease (PD) are prevalent diseases that affect an aging population. Previous systematic reviews and meta-analyses have explored the relationship between diabetes and the risk of PD, but […]
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Randomized Trial of Focused Ultrasound Subthalamotomy for Parkinson’s Disease
November 7, 2021
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Main idea: Focused ultrasound subthalamotomy treatment improved neuromotor function of Parkinson’s disease in selected patients with asymmetric signs. But such a treatment also had adverse events, such as speech and gait disturbances, weakness on the treated side, and dyskinesia. Abstract  The subthalamic nucleus is the preferred neurosurgical target for deep-brain stimulation to treat cardinal motor […]
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Association of Multiple Dopamine D3 Receptor Gene 3’UTR Polymorphisms with Susceptibility to Parkinson’s Disease and Clinical Efficacy of Piribedil Therapy
November 7, 2021
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Main idea: certain genetic polymorphisms of DRD3, such as rs76126170, rs9868039, and rs9817063 are connected to Parkinson’s disease susceptibility and also high efficiency of piribedil treatment. Abstract To investigate the correlation between the Dopamine D3 receptor (DRD3) 3’untranslated region (3’UTR) gene polymorphism and susceptibility to Parkinson’s disease (PD) and the clinical effect of the DRD2 […]
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Ventilatory Impairments Associated with Parkinson’s Disease: A Systematic Review and Meta-Analysis
November 7, 2021
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Main idea: the recent study proved that Parkinson’s disease affects the respiratory system through the neuromuscular system. The patients have impaired respiratory capacities that are related to the Parkinson’s disease severity, which can be used in diagnostics and respiratory conditions treatment. Abstract  Parkinson’s disease affects the neuromuscular system producing a loss of muscle strength that […]
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Classifications of Neurodegenerative Disorders Using a Multiplex Blood Biomarkers-Based Machine Learning Model
November 7, 2021
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Main idea: plasma levels of amyloid-beta 42 (Aβ42), Aβ40, total Tau, p-Tau181 are predictive markers of Alzheimer’s disease and Parkinson’s disease. Abstract  Easily accessible biomarkers for Alzheimer’s disease and related neurodegenerative disorders are urgently needed. In this study, we aimed to develop machine learning algorithms using multiplex blood-based biomarkers. Plasma samples were obtained from healthy […]
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Minimum Alveolar Concentration-Awake of Sevoflurane is Decreased in Patients with Parkinson’s Disease: An Up-and-Down Sequential Allocation Trial
November 7, 2021
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Main idea: Sevoflurane is a sweet-smelling, nonflammable, highly fluorinated methyl isopropyl ether used as an inhalational anesthetic. A recent study demonstrated that patients with Parkinson’s disease require a smaller concentration of sevoflurane compared to patients without Parkinson’s disease.  Clinicians should avoid an overdose of sevoflurane in patients with Parkinson’s disease. Abstract  An increasing number of […]
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Postural sway correlates with cognition and quality of life in Parkinson’s disease
November 7, 2021
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Main idea: Patients with Parkinson’s disease can be diagnosed through posture sway which makes diagnostics easier. Abstract  The severity of Parkinson’s disease (PD) is difficult to assess objectively owing to the lack of a robust biological marker of underlying disease status. The current standard tool is the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS). Postural sway […]
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