Beneficial effects of nano-curcumin supplement on depression and anxiety in diabetic patients with peripheral neuropathy: A randomized, double-blind, placebo-controlled clinical trial

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Main idea: Nano‐curcumin is superior to placebo in reducing depression and anxiety scores in patients with neuropathy. The nano‐curcumin supplementation was well tolerated. However, further studies with long‐term duration and various doses are required to confirm the results.

Abstract: Depression in patients with diabetes is associated with poor glycemic control and linked to an increased risk for diabetes complications such as neuropathy. They received 80 mg of nano-curcumin or placebo capsules daily for 8 weeks. The depression, anxiety, and stress level were measured by the Depression, Anxiety, Stress Scale (DASS-21-items) questionnaire before and after the intervention. At baseline and end of the study, anthropometric measurements, dietary intake, physical activity, glycemic indices, and severity of neuropathy were assessed. Changes in stress score were not statistically significant between the two groups. These findings suggested that nano-curcumin supplementation for 8 weeks was effective in reducing depression and anxiety scores in patients with diabetic polyneuropathy. Curcumin has shown potential antidepressant-like activities in some studies. The participants were allocated randomly to the intervention and control of n 40 groups.

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