Science Allergy

Main idea: The JC pollen sublingual immunotherapy tablet relieved nasal and ocular symptoms, lowered the medication use and improved the quality of life in a treatment duration-dependent manner. Continuous dosing regimens appear to enhance the efficacy of the drug. Abstract A randomized, placebo-controlled, double-blind clinical trial to investigate the optimal dose and long-term efficacy and […]

Main idea: Dual therapy with both sublingual immunotherapy tablets administered within 5 min after 4 weeks of monotherapy with House dust mite or Japanese cedar pollen tablet was well tolerated and induced the expected immunological responses. Abstract Background: There were no studies of dual administration of sublingual immunotherapy (SLIT) tablets for perennial and seasonal allergic […]

Main idea: Treatment with grass allergen peptides led to an improvement in allergic rhinoconjunctivitis symptoms after 3 intervening GPSs, corresponding to up to 2 years off treatment. Abstract Grass allergen peptides are in development for the treatment of grass pollen-induced allergic rhinoconjunctivitis. A previous randomized, placebo-controlled study demonstrated that grass allergen peptides significantly improved total […]

Main idea: All vaccination regimens were found to be safe and tolerable. While there were no overall differences between regimen intradermal injection of IIV3, and double injection of IIV3 by intramuscular route, showed higher responses compared to the other same-route regimens. Abstract Seasonal influenza results in significant morbidity and mortality worldwide, but the currently licensed […]

Main idea: Intralymphatic immunotherapy was safe and effective for Japanese cedar pollinosis. The clinical effects remained for 1-2 years. Abstract Intralymphatic immunotherapy (ILIT) for allergic patients requires only a few intralymphatic injections of the allergen. However, the effectiveness and safety of Japanese cedar pollinosis are unclear. The objectives of this study were to clarify whether […]

Main idea: Overall, as reflected in a simple complete blood count, cetirizine critically diminished immediate and late innate immune responses subsequent to allergen exposure. Abstract IgE-mediated inflammatory responses upon allergen contact in allergic rhinitis (AR) are associated with rapid alterations in circulating blood cell numbers detectable in a complete blood count (CBC). The aim of […]

Main idea: In this proof-of-concept trial intralymphatic immunotherapy was well tolerated and improved the symptoms and medication use associated with allergic rhinoconjunctivitis caused by mountain cedar pollen. Abstract Allergen immunotherapy can provide long-term benefits, including symptomatic relief and reduced disease progression, but it requires a prolonged regimen that presents barriers to patient adherence. Thus, there […]

Main idea: Nitric oxide levels are higher in allergic rhinitis, particularly when using high aspiration flows and in younger patients, who often perceive this condition as a source of disability. Abstract Nasal nitric oxide (nNO) is considered a biomarker of nasal inflammation. The objective of the study was to perform a systematic review with meta-analysis […]

Main idea: Among critically ill patients with sepsis treatment with vitamin C, thiamine, and hydrocortisone, compared with placebo, did not significantly increase ventilator- and vasopressor-free days within 30 days. Abstract Sepsis is a common syndrome with substantial morbidity and mortality. A combination of vitamin C, thiamine, and corticosteroids has been proposed as a potential treatment […]

Main idea: The study demonstrates that providing a placebo and enhancing the encounter remotely is possible, but their effectiveness might be lower in comparison with the previous studies relying on physical patient-provider interaction. The study raises questions for future research about the potential and challenges of remote placebo studies and virtual clinical encounters. Abstract Placebos […]