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Science Diabetes mellitus

Incretin mimetics and sodium-glucose co-transporter 2 inhibitors as monotherapy or add-on to metformin for treatment of type 2 diabetes: a systematic review and network meta-analysis
November 7, 2021
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Shubing Jia 1, Zhiying Wang 1, Ruobing Han 1, Zinv Zhang 1, Yuping Li 1, Xiaotong Qin 1, Mingyi Zhao 1, Rongwu Xiang 2, Jingyu Yang 3 4 Main idea: Both GLP-1RAs and SGLT-2is have their own advantages in efficacy and safety. Monotherapy is beneficial for reducing the risk of hypoglycemia. The recommendation should be […]
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Early-onset type 2 diabetes: A high-risk factor for proliferative diabetic retinopathy (PDR) in patients with microalbuminuria
November 7, 2021
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Xinlu Lv 1, Xi Ran 2, Xiangjun Chen 1, Ting Luo 1, Jinbo Hu 1, Yue Wang 1, Zhiping Liu 1, Qianna Zhen 1, Xiurong Liu 1, Li Zheng 1, Ying Tang 1, Qinying Zhao 1, Shichao Han 3, Yangmei Zhou 1, Wenjin Luo 1, Lina Yang 1, Qifu Li 1, Zhihong Wang 1 Main […]
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RAS inhibition modulates kynurenine levels in a CKD population with and without type 2 diabetes mellitus
November 7, 2021
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Valeria Cernaro 1, Saverio Loddo 2, Vincenzo Macaione 2, Valentina Teresa Ferlazzo 2, Rosalia Maria Cigala 3, Francesco Crea 3, Concetta De Stefano 3, Antonina Rita Rosalia Genovese 4, Guido Gembillo 4, Davide Bolignano 5, Domenico Santoro 4, Roberto Vita 6, Michele Buemi 4, Salvatore Benvenga 6 7 8 Main idea: These findings may contribute […]
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Hyperbaric oxygen but not hyperbaric air increases insulin sensitivity in men with type 2 diabetes mellitus
November 7, 2021
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David C Wilkinson 1 2 3, Ian M Chapman 2, Leonie K Heilbronn 2 Main idea: Insulin sensitivity was not changed in hyperbaric air. Abstract Introduction: We have previously shown that hyperbaric oxygen treatment (HBOT) increased insulin sensitivity in men who were obese or overweight, both with and without type 2 diabetes. The aim of […]
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Effects of Dapagliflozin on Epicardial Fat Thickness in Patients with Type 2 Diabetes and Obesity
November 7, 2021
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Gianluca Iacobellis 1, Silvia Gra-Menendez 1 Main idea: Dapagliflozin causes a rapid and significant EAT reduction that could be independent of weight loss. Abstract Objective: Dapagliflozin is a selective sodium-glucose cotransporter 2 inhibitor. It improves glucose control and induces moderate weight loss in patients with type 2 diabetes mellitus. It has been shown to reduce […]
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Efficacy of individualized education in patients with type 2 diabetes mellitus: A randomized clinical study protocol
November 7, 2021
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Li Huang 1, Hongyan Guo 2, Lihua Xiu 1, Haowen Wang 1 Main idea: Individualized diabetes education may improve the clinical outcomes in patients with type 2 DM. Abstract Objective: To assess the effect of the program of individualized diabetes education on type 2 diabetes mellitus (DM) patients. Methods: A single-center randomized controlled trial will […]
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Glucagon-like Peptide 1 Receptor Agonists, Diabetic Retinopathy and Angiogenesis: The AngioSafe Type 2 Diabetes Study
November 7, 2021
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Bénédicte Gaborit 1 2, Jean-Baptiste Julla 3 4, Samaher Besbes 5, Matthieu Proust 5, Clara Vincentelli 1 2, Benjamin Alos 5, Patricia Ancel 1, Fawaz Alzaid 4, Rodrigue Garcia 5, Philippe Mailly 5, Florence Sabatier 1, Maud Righini 6, Pierre Gascon 6 7, Frédéric Matonti 6 7, Marie Houssays 8, Louisa Goumidi 1, Lucile Vignaud […]
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Predicting post one-year durability of glucose-lowering monotherapies in patients with newly-diagnosed type 2 diabetes mellitus – A MASTERMIND precision medicine approach (UKPDS 87)
November 7, 2021
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Olorunsola F Agbaje 1, Ruth L Coleman 2, Andrew T Hattersley 3, Angus G Jones 3, Ewan R Pearson 4, Beverley M Shields 3, Rury R Holman 2, MASTERMIND consortium Main idea: Post one-year glycaemic durability can be predicted robustly in individuals with newly-diagnosed T2D who achieve HbA1c values < 7.5% one year after commencing […]
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Tofogliflozin does not delay progression of carotid atherosclerosis in patients with type 2 diabetes: a prospective, randomized, open-label, parallel-group comparative study
November 7, 2021
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Naoto Katakami 1 2, Tomoya Mita 3, Hidenori Yoshii 4, Toshihiko Shiraiwa 5, Tetsuyuki Yasuda 6, Yosuke Okada 7, Keiichi Torimoto 7, Yutaka Umayahara 8, Hideaki Kaneto 9, Takeshi Osonoi 10, Tsunehiko Yamamoto 11, Nobuichi Kuribayashi 12, Kazuhisa Maeda 13, Hiroki Yokoyama 14, Keisuke Kosugi 15, Kentaro Ohtoshi 16, Isao Hayashi 17, Satoru Sumitani 18, […]
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Rho kinase cascade activation in circulating leukocytes in patients with diabetes mellitus type 2
November 7, 2021
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Maria Paz Ocaranza 1 2 3, Patricio Valderas 4, Jackeline Moya 1, Luigi Gabrielli 1 3, Iván Godoy 1, Samuel Córdova 1, Paul Mac Nab 1, Lorena García 5, Luis Farías 1, Jorge E Jalil 6 7 Main idea: ROCK inhibition might have an additional role in the prevention and treatment of T2D. Abstract Background: […]
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