Science Irritable bowel syndrome (IBS)

Main idea: This meta-analysis provides epidemiological evidence of a link between endometriosis and IBS, highlighting two or more times higher risk of IBS in women with endometriosis compared to women without the condition. Abstract Irritable bowel disease and endometriosis are two common diseases characterized by chronic inflammation state and recurrent abdominal pain. As a consequence […]

Main idea: Amitriptyline is FDA approved medication to treat depression in adults, and it shows beneficial effects against IBS. Abstract Amitriptyline is an FDA-approved medication to treat depression in adults. The Non-FDA approved indications are anxiety, post-traumatic stress disorder, insomnia, chronic pain (diabetic neuropathy, fibromyalgia), irritable bowel syndrome, interstitial cystitis (bladder pain syndrome), migraine prophylaxis, […]

Abstract Immediate-release (IR) formulation of linaclotide 290 μg improves abdominal pain and constipation (APC) in patients with irritable bowel syndrome (IBS) with constipation. Overall, 532 patients were randomized; the mean age was 45.1 years, most were women (83.3%) and White (64.7%). All linaclotide DR1 and MD-7246 groups experienced greater improvements in abdominal pain from baseline […]

Main idea: Diarrhea-predominant irritable bowel syndrome (IBS-D)  symptoms can be decreased by the Tong-Xie-An-Chang Decoction (TXACD). Abstract Diarrhea-predominant irritable bowel syndrome (IBS-D) is a kind of functional gastrointestinal disorder with obscure pathogenesis. The exploration on differential gene expression and cell heterogeneity of T lymphocytes in peripheral blood in IBS-D patients still remains unknown. Clinicians tend […]

Main idea: This is the meta-analysis to examine the use of opioid receptor modulators in IBS, and few adverse events were reported in the available trials. Compared with the control group, eluxadoline has a better effect on improving IBS global symptoms and abdominal pain and has statistical significance and showed a low rate of constipation […]

Main idea: B coagulans LBSC are safe for human consumption and efficacious in alleviating overall pathophysiological symptoms of IBS and thereby improving inclusive quality of life. Abstract Bacteriotherapy shows a promising impact on alleviating clinical conditions of IBS and associated functional gastrointestinal disorders. B coagulans LBSC is a genetically and phenotypically safe probiotic strain used […]

Main idea: The Tiaoshen acupuncture method combined with electroacupuncture has a significant effect in the treatment of IBS-D, can significantly reduce the symptoms of abdominal pain, abdominal distension, and diarrhea in patients, effectively improve patients’ quality of life and depression condition, the effect is better than the simple electroacupuncture treatment. Abstract The main goal of […]

Main idea: The study suggests that Helicobacter pylori may have a positive effect on the development of IBS. Although the differences were not statistically significant, there were significant differences among subgroups of patients. Abstract In recent years, the incidence of IBS has gradually increased, and it is considered one of the most common functional gastrointestinal […]

Main idea: Current findings demonstrated that lubiprostone is beneficial in terms of SBM frequency for CIC, IBS-C, and OIC. In terms of abdominal symptoms, the most pronounced effect was seen for abdominal pain in IBS-C patients. Abstract Lubiprostone is a type 2 chloride channel activator that has been shown to be efficacious and safe in […]