Allergen-specific IgG + memory B cells are temporally linked to IgE memory responses
Main idea: For the first time, it was shown that on mucosal allergen exposure human IgE memory resides in allergen-specific IgG+ memory B cells. These cells rapidly switch isotype, expand into short-lived IgE+immune cells and serve as a potential target for therapeutic intervention. Abstract IgE is the least abundant immunoglobulin, which is tightly regulated. IgE-producing […]
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