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Science Allergy

A pilot study on the allergen-specific IgE to molecular components on polysensitized mite allergic asthmatic patients in Guangzhou, China
November 7, 2021
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Abstract The objective of the study was to investigate the allergen sensitization profile of allergic asthma patients in southern China with the help of multiplex microarray-based component resolved diagnosis (CRD). Blood serum samples from 57 polysensitized mite allergic asthmatic patients in a tertiary referral center of southern China were tested with multiplex CRD (ISAC) for […]
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Discriminating severe seasonal allergic rhinitis. Results from a large nation-wide database
November 7, 2021
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Main idea: The ARPhyS scale seems the best method to target patients with severe seasonal allergic rhinitis. In the present study optimal discrimination cut-offs were highlighted. This tool could be implemented in a daily practice to identify severe patients who need a specialized intervention. Abstract Allergic rhinitis (AR) is a chronic disease affecting a large […]
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Sublingual allergen immunotherapy with a liquid birch pollen product in patients with seasonal allergic rhinoconjunctivitis with or without asthma
November 7, 2021
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Main idea: This study confirmed both the clinical efficacy and safety of a sublingual liquid birch pollen extract in adults with birch pollen allergy in a pivotal phase III trial. Abstract Background: Sublingual allergen immunotherapy (SLIT) has been demonstrated to be both clinically efficacious and safe. However, in line with the current regulatory guidance from […]
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Subdominant and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem
November 7, 2021
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Abstract Both natural influenza infection and current seasonal influenza vaccines primarily induce neutralizing antibody responses against highly diverse epitopes within the “head” of the viral hemagglutinin (HA) protein. There is an increasing interest in redirecting immunity toward the more conserved HA stem or stalk as a means of broadening protective antibody responses. HA stem-specific B […]
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Triamcinolone Acetonide versus Fluticasone Propionate in the Treatment of Perennial Allergic Rhinitis: A Randomized, Parallel-Group Trial
November 7, 2021
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Main idea: Triamcinolone acetonide proved to be non-inferior to fluticasone propionate in adult patients with perennial allergic rhinitis; both treatments decreased rhinitis symptoms and showed a good safety profile. Abstract Intranasal sprays are recommended as targeted therapy for allergic rhinitis (AR). Triamcinolone acetonide is a nasal corticosteroid preparation indicated for the treatment of seasonal and […]
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Efficacy and safety of birch pollen allergoid subcutaneous immunotherapy: A 2-year double-blind, placebo-controlled, randomized trial plus 1-year open-label extension
November 7, 2021
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Main idea: Although the primary endpoint was not reached for the Full Analysis Set, a significant and clinically relevant effect on Symptom Medication Score was clearly demonstrated for the subgroup of patients in the northeastern region of Europe, where birch is the predominant tree species. Proving efficacy of birch allergen subcutaneous immunotherapy is challenging due […]
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Efficacy of a Novel Intranasal Formulation of Azelastine Hydrochloride and Fluticasone Propionate, Delivered in a Single Spray, for the Treatment of Seasonal Allergic Rhinitis: Results from Russia
November 7, 2021
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Main idea: MP-AzeFlu was superior to AZE in reducing moderate-to-severe seasonal allergic rhinitis symptoms, providing earlier and better symptom relief. Abstract The novel intranasal formulation of azelastine hydrochloride (AZE) and fluticasone propionate (FP) in a single spray (MP-AzeFlu) was compared with a first-line intranasal antihistamine spray (AZE) in Russian seasonal allergic rhinitis (SAR) patients. Moderate-to-severe […]
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Fast up-dosing with a birch allergoid is safe and well-tolerated in allergic rhinitis patients with or without asthma
November 7, 2021
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Main idea: Seven-dose treatment and four-dose treatment of allergic rhinitis are comparable in terms of safety and tolerability. Abstract The aim of the study was to investigatesubcutaneous immunotherapy efficiency in treating allergic rhinoconjunctivitis and asthma but is still inconvenient when heavy schedules are used. In this open-label, Phase II trial, 130 adults were randomized 1:1 […]
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Academic achievement of adolescents with asthma or atopic disease
November 7, 2021
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Main idea: Having asthma or an atopic disease during childhood or adolescence does not negatively impact academic performance. This information can be used by clinicians when talking with children and parents about the implications of living with asthma or atopic disease. Abstract Over a fifth of children and adolescents suffer from asthma or atopic disease. […]
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Real-life safety of 5-grass pollen tablet in 5-to-9-year-old children with allergic rhinoconjunctivitis
November 7, 2021
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Main idea: The safety profile of 5-grass tablet in pediatric allergic rhinitis patients aged 5 to 9 years was consistent with safety findings in older patients. Abstract Although 5-grass pollen sublingual immunotherapy has a good safety profile in controlled clinical trials, additional safety information among pediatric patients in a real-world setting would be useful. The […]
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