Science Neuropathy

Main idea: In daily clinical routine, good results have been achieved with the application of electrotherapy for Chemotherapy-induced peripheral neuropathy. This pilot study can provide important evidence about the therapeutic effects of home-based HTEMS in Chemotherapy-induced peripheral neuropathy, which is a worldwide concern in oncologic patients. Abstract: Chemotherapy-induced peripheral neuropathy (CIPN) is a worldwide concern in patients […]

Main idea: Combination of Tocotrienol and Rich Vitamin E increases neuron conduction and prevents neuropathy progression. Abstract: Chronic hyperglycemia increases oxidative stress, activates inflammatory pathways, and reduces nerve growth factor (NGF) among diabetic patients, which contributes to the development of diabetic peripheral neuropathy (DPN). Tocotrienol-Rich Vitamin E (Tocovid) possesses potent antioxidant and anti-inflammatory properties which are postulated […]

Main idea: This study suggests that in situ decompression for mild ulnar neuropathy at the elbow results in faster relief of symptoms when compared to conservative treatment, but at long-term follow-up, no differences were observed. Abstract: The best treatment strategy for mild ulnar neuropathy at the elbow (UNE) is not known, due to the lack of trials […]

Main idea: The dragon-tiger fighting needling therapy reduces pain symptoms in diabetic neuropathy and increases neuron connectivity. Abstract: To compare the clinical therapeutic effect on painful diabetic peripheral neuropathy (PDPN) between dragon-tiger fighting needling and pregabalin capsules. A total of 60 patients with PDPN were randomized into an observation group and a control group, 30 cases in […]

Main idea: This study gives medical evidence for alprostadil combined with Alpha-lipoic acid in the treatment of diabetic peripheral neuropathy. Abstract: The pathogenesis of diabetic peripheral neuropathy is more complex and it is not yet clear, but studies have shown that microangiopathy and oxidative stress responses are closely related to their pathogenesis. At present, the treatment […]

Main idea: Treatment with D5W is a suitable injectate for perineural injection in patients with ulnar neuropathy at the elbow. Abstract: To assess the effects of perineural corticosteroid and 5% dextrose water (D5W) injections in patients with mild to moderate ulnar neuropathy at the elbow (UNE). Design: Prospective, randomized, double-blind, controlled trial (6-month follow-up). Setting: Outpatients […]

Main idea: High-intensity combined aerobic and resistance exercise may be safely prescribed for inactive individuals with type 2 diabetes and may reduce musculoskeletal pain but not neuropathic symptoms. Abstract: People with type 2 diabetes (T2D) have a greater prevalence of musculoskeletal and neuropathic pain. This exploratory analysis investigated whether the exercise of different intensities leads to […]

Main idea: Chemotherapy-induced peripheral neuropathy represents a major concern in cancer therapy. There is limited evidence-based data available for prophylaxis and treatment of this condition. Early start of functional exercises during chemotherapy is recommended. Existing data on pharmaceutical treatment of chemotherapy-induced peripheral neuropathy allow weak recommendations for duloxetine. Given the paucity of available alternative treatment strategies […]

Main idea: Mindfulness and not pain catastrophizing significantly mediated outcomes. The moderating effects of patient characteristics were not significant, although some linear patterns where J Behav Med 123 found guide future research. Post-hoc analyses suggested that some mediated effects were additionally moderated by the duration of diabetes. Abstract: Painful diabetic peripheral neuropathy (PDPN) is a chronic pain […]

Main idea: The neuropathological findings in gluten-related neurological disorders are widespread and not limited by the cerebellum in the brain. Information on the nature of the chronic inflammation (e.g. lymphocytic infiltration) is still unclear and requires further research. Abstract: Gluten-related neurological disorders (GRND) represent a spectrum of neurological manifestations that are triggered by gluten. In coeliac disease, […]