Main idea: Mixed connective tissue disease and trigeminal neuropathy are often found together in patients. Mixed connective tissue disease treatment can reduce trigeminal neuropathy progression.
Abstract: The present study aims to analyze clinical and laboratory features of mixed connective tissue disease (MCTD)-associated Trigeminal Neuropathy (TN). Clinical records of 12 cases of MCTD-associated Trigeminal Neuropathy diagnosed in Peking University People’s Hospital from January 2008 to October 2019 were analyzed retrospectively. The present study included 12 cases with 1 male and 11 females, where the age group was between 27-53 years. In 1 case, Trigeminal Neuropathy was developed before the diagnosis of MCTD. Whereas, TN and MCTD occurred simultaneously in 1 case. The study found that the main clinical features of MCTD-associated Trigeminal Neuropathy included the Raynaud phenomenon (12 cases), arthritis (10 cases), edema of fingers (9 cases), myositis (6 cases), and pulmonary involvement (11 cases). Antinuclear antibodies (ANA) and high titers of anti-U1-RNP antibodies can be detected in the serum of all patients. Neurological symptoms improve slowly. The findings indicate that TN is often associated with activated MCTD. Thus, intensive treatment of MCTD can control the progression of TN.