Effect of rTMS on Parkinson’s cognitive function: a systematic review and meta-analysis

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Main idea: repetitive transcranial magnetic stimulation can improve cognitive function in Parkinson’s disease patients.

Abstract 

To evaluate the effects and optimal parameters of repetitive transcranial magnetic stimulation (rTMS) on cognition function of patients with Parkinson’s disease (PD) and to estimate which cognitive function may obtain more benefits from rTMS. The articles dealing with rTMS on cognitive function of PD patients were retrieved from the databases until April 2019. Outcomes of global cognitive function and different cognitive domains were extracted. Fourteen studies involving 173 subjects were included in this meta-analysis. The significant effect size was observed with the mini-mental state examination (MMSE) for the global cognitive outcome. The significant effect sizes for executive function were found with multiple sessions of high-frequency rTMS. All of the other cognitive domains did not obtain significant effects. Multiple sessions of high-frequency rTMS over the DLPFC may have a positive effect on executive function in PD patients. Further well-designed studies with large sample sizes are needed to verify our results and ascertain the long-term effects of rTMS.

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