Effectiveness of acupuncture combined mecobalamin in the treatment of elderly diabetic peripheral neuropathy: A protocol of systematic review and meta-analysis

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Main idea: Combination of acupuncture and mecobalamin are efficient in the treatment of elderly diabetic peripheral neuropathy.

Abstract: Although previous studies have reported the effectiveness of acupuncture combined mecobalamin (AM) in the treatment of elderly diabetic peripheral neuropathy (EDPN), no systematic study has assessed its effectiveness and safety. Thus, this study will evaluate the effectiveness and safety of AM for the treatment of patients with EDPN. Bibliographic electronic databases will be searched as follows: Cochrane Library, PUBMED, EMBASE, CINAHL, PsycINFO, WANGFANG, and China National Knowledge Infrastructure. All study selection, information extracted, and study quality evaluation will be performed by 2 independent authors. Although previous studies have reported the effectiveness of acupuncture combined mecobalamin (AM) in the treatment of elderly diabetic peripheral neuropathy (EDPN), no systematic study has assessed its effectiveness and safety. RevMan 5.3 software will be used for data pooling and meta-analysis performance if it is possible. All of them will be searched from each database initial to March 1, 2020, without language restrictions. Any disagreements between 2 authors will be resolved by a third author via discussion. This study will provide a synthesis of current evidence of AM for patients with EDPN through the primary outcome of the glycemic profile, and secondary of neuropathic pain intensity, plantar tactile sensitivity, sensory nerve conduction velocity, and motor nerve conduction velocity, health-related quality of life, and adverse events.

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