Efficiency of stem cell based therapy in the treatment of diabetic foot ulcer: a meta-analysis


Main idea: The present meta-analysis indicates that stem cell-based therapy can enhance the healing of diabetic foot ulcers and is associated with lesser pain, lower amputation rate and improved prognosis compared with normal treatment. Well-designed randomized controlled trials are required in the future in order to confirm and update these findings.


Diabetic foot ulcer is a chronic, refractory, frequent complication in diabetic patients. Its treatment often requires multidisciplinary joint efforts, diverse strategies have been adopted to address this annoying issue, including stem cell-based therapy/acellular dermal matrix/negative pressure wound therapy etc. However, consensus has not been reached. To assess the current evidence regarding the efficiency and potential advantages of stem cell-based therapy compared with conventional standard treatment and/or placebo in the treatment of diabetic foot ulcers. A total of 7 studies that involved 224 diabetic foot patients, classified as Wagner grades 1-5, were analyzed.


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