Improvement in Cardiovascular Autonomic Neuropathy After High-Dose Vitamin D Supplementation in Patients With Type 1 Diabetes

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Main idea: The study proves that high-dose vitamin D supplementation can improve symptoms of cardiovascular autonomic neuropathy in Type 1 Diabetes Mellitus patients. The treatment showed no adverse effects, such as hemoglobin level, blood pressure levels, lipids, and insulin dose.

Abstract: Cardiovascular autonomic neuropathy (CAN) is associated with diabetes mellitus, increasing morbidity and mortality. Some cross-sectional studies associated CAN with low 25-hydroxyvitamin D levels. Our study aimed to evaluate the effect of high-dose vitamin D (VD) supplementation on CAN in Type 1 Diabetes Mellitus (T1DM) patients. We performed a prospective study with 23 patients diagnosed with T1DM and CAN. Subjects with VD levels 30 ng/ml received 10,000 IU/day the ones with VD levels between 30-60 ng/ml were given 4,000 IU/day for 12 weeks. There was an improvement in CAN parameters related to resting heart rate variability, mean length of regular RR intervals, and standard deviation of all NN intervals and frequency domain parameters, and total Power . Also, there was a correlation between absolute VD level variation and posttreatment High Frequency (%), as well as among percent variation in VD level and end-of-study Low Frequency/High-Frequency ratio. The study proves that high-dose vitamin D supplementation can improve symptoms of cardiovascular autonomic neuropathy in Type 1 Diabetes Mellitus patients. The treatment showed no adverse effects, such as hemoglobin level, blood pressure levels, lipids, and insulin dose.

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