Mangiferin inhibits cell migration and angiogenesis via PI3K/AKT/mTOR signaling in high glucose‑ and hypoxia‑induced RRCECs



Mangiferin is a prominent active component that can be derived from several traditional herbs, including Mangifera indica L., Anemarrhena asphodeloides Bge., and Belamcanda chinensis (L.) DC., which displays antidiabetic properties. Diabetic retinopathy (DR), a serious complication caused by diabetes, is the leading cause of blindness. The present study aimed to evaluate the beneficial effects of mangiferin on cell cultures mimicking diabetes cells.

The results demonstrated that mangiferin notably inhibited hypoxia‑induced migration of the cells and angiogenesis. On the other hand, mangiferin activated proteins characteristic to wound healing.

Conclusion: Collectively, the results of the present study suggested that mangiferin suppressed angiogenesis and stimulated healing process.


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