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Science Diabetes ulcers treatment

Photobiomodulation in diabetic wound healing: A review of red and near-infrared wavelength applications
November 7, 2021
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Abstract The development of a painless, non-invasive, and faster way to diabetic wound healing is at the forefront of research. The complexity associated with diabetic wounds makes it a cause for concern amongst diabetic patients and the world at large. Irradiation of cells generates a photobiomodulatory response on cells and tissues, directly causing alteration of […]
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A Multicenter, Blinded, Randomized Controlled Clinical Trial Evaluating the Effect of Omega-3-Rich Fish Skin in the Treatment of Chronic, Nonresponsive Diabetic Foot Ulcers
November 7, 2021
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Abstract Omega-3-rich fish skin grafts have been shown to accelerate wound healing in full-thickness wounds.The goal of this study was to compare the fish skin graft with standard of care (SOC) using collagen alginate dressing in the management of treatment-resistant diabetic foot ulcers (DFUs), defined as superficial ulcers not involving tendon capsule or bone. Patients […]
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LncRNA GAS5 activates the HIF1A/VEGF pathway by binding to TAF15 to promote wound healing in diabetic foot ulcers
November 7, 2021
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Abstract A diabetic foot ulcer (DFU) is one of the most devastating complications of diabetes. It has been reported that lncRNA GAS5 plays a vital role in wound healing in diabetic foot ulcers. The non-coding genome has previously been regarded as “junk” DNA; however, emerging evidence suggests that the non-coding genome accounts for some of […]
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Combined Antioxidant-Antibiotic Treatment for Effectively Healing Infected Diabetic Wounds Based on Polymer Vesicles
November 7, 2021
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Abstract Infected diabetic wounds are difficult to heal due to high reactive oxygen species (ROS) concentrations and recurrent infections.  Reactive oxygen species (ROS) serve as cell signaling molecules for normal biologic processes. However, the generation of ROS can also provoke damage to multiple cellular organelles and processes, which can ultimately disrupt normal physiology. Such wounds […]
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[Research advances on the effects and mechanism of curcumin in promoting diabetic wound healing]
November 7, 2021
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Abstract in English, Chinese Diabetic wound is a common complication of diabetes, and the effect of current treatment is still poor. Curcumin has many pharmacological effects, such as anti-inflammatory, anti-oxidation, antimicrobial, anti-cancer, and improving insulin resistance. Conclusion: Curcumin can be used as a co-treatment in diabetic wound healing in combination with regular treatment.
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Conservative Surgery for Diabetic Foot Osteomyelitis is not Associated With Longer Survival Time Without Recurrence of Foot Ulcer When Compared With Amputation
November 7, 2021
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Abstract Conservative surgery of diabetic foot osteomyelitis (DFO) in which bone infection is removed without amputation could minimize the biomechanical changes associated with foot surgery. We hypothesize that patients who undergo conservative surgery will have a longer survival time without recurrence of foot ulcers and further amputations than those who undergo any type of amputation […]
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Onychomycosis and Tinea Pedis in the Feet of Patients With Diabetes
November 16, 2021
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Abstract This study aimed to determine the prevalence of onychomycosis and interdigital tinea pedis in a cohort of Spanish patients with diabetes in whom onychomycosis was clinically suspected (n = 101). Samples from a first toenail scraping and the fourth toe clefts were subjected to potassium hydroxide direct vision and incubated in Sabouraud and dermatophyte […]
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Protective effects of klotho on palmitate-induced podocyte injury in diabetic nephropathy
November 7, 2021
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Abstract The anti-aging gene, klotho, has been identified as a multi-functional humoral factor and is implicated in multiple biological processes. However, the effects of klotho on podocyte injury in diabetic nephropathy are poorly understood. Thus, the current study aims to investigate the renoprotective effects of klotho against podocyte injury in diabetic nephropathy. We examined lipid […]
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MSC-Derived Extracellular Vesicles to Heal Diabetic Wounds: a Systematic Review and Meta-Analysis of Preclinical Animal Studies
November 7, 2021
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Abstract Extracellular vesicles from mesenchymal stromal cells (MSC-EVs) have shown promise in wound healing.  Extracellular vesicles are lipid bilayer-delimited particles that are naturally released from a cell and, unlike a cell, cannot replicate.  Extracellular vesicles range in diameter from near the size of the smallest physically possible unilamellar liposome (around 20-30 nanometers) to as large […]
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Sp1-mediated upregulation of Prdx6 expression prevents podocyte injury in diabetic nephropathy via mitigation of oxidative stress and ferroptosis
November 7, 2021
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Abstract Glomerular podocyte damage is considered to be one of the main mechanisms leading to Diabetic nephropathy. However, the relevant mechanism of podocyte injury is not yet clear. This study aimed to investigate the effect of peroxiredoxin 6 (Prdx6) on the pathogenesis of podocyte(kidney cells) injury induced by high glucose (HG). As a result, cells […]
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