Main idea: In regards to the progressive nature of diabetic peripheral neuropathy and the limited time of the combined aerobic and resistance treatment, it seems that the little variations having occurred in KLC-1 serum, aerobic endurance, and trunk strength can be positively taken and evaluated, and although these variations are not statistically significant, it can be predicted that probably longer periods of these pieces of training can bring about effective results. Regarding the fact that the lower body strength increase is significant, it can be concluded that the combined aerobic-resistance training has had a significant effect on the lower body strengthening factors, and it is felt that more research is required to be conducted in this field.
Abstract: Diabetic peripheral neuropathy is one of the most common chronic complications of diabetics which causes nerve damage and muscle strength decrease in patients. This in turn results in imbalance leading to the diabetic patients’ daily activity disparity. The present investigation was conducted to specifically study the effects of combined training (resistance-aerobic) on serum kinesin-1 and physical function in type 2 diabetes patients with diabetic peripheral neuropathy. 24 diabetic neuropathic females were randomly selected out and divided into two experimental and control groups. The experimental group received resistance-aerobic training for 3 sessions for eight weeks. The exercise training included resistance exercises with 2-3 sets, 6-7 exercise stations, 8-12 repetitions (reps), and 3-5 minutes of rest in between the exercises, and the aerobic exercises contained 50-65% of heart rate reserve (HRR) for 3 minutes with 30 seconds of rest interval between sets and 5-10 repetitions. Results show that the serum kinesin-1 level and aerobic endurance declined after eight weeks of combined (resistance-aerobic) exercise training, but this decrease was not significant. The upper body strength increased but it was not significant, while the lower body showed a significant strength increase. Concerning the progressive nature of diabetic peripheral neuropathy, it seems that even the little changes resulting from the combined exercise training can be useful. Nevertheless, more research is required in this area.