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Science Diabetes mellitus

Remission of Type 2 Diabetes Following a Short-term Intervention With Insulin Glargine, Metformin, and Dapagliflozin
November 7, 2021
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Natalia McInnes 1 2, Stephanie Hall 2, Farah Sultan 1, Ronnie Aronson 3, Irene Hramiak 4, Stewart Harris 4, Ronald J Sigal 5, Vincent Woo 6, Yan Yun Liu 2, Hertzel C Gerstein 1 2 Main idea: The primary outcome of diabetes remission at 24 weeks was not statistically significantly different. However, our overall results […]
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Effects of Diet versus Gastric Bypass on Metabolic Function in Diabetes
November 7, 2021
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Mihoko Yoshino 1, Brandon D Kayser 1, Jun Yoshino 1, Richard I Stein 1, Dominic Reeds 1, J Christopher Eagon 1, Shaina R Eckhouse 1, Jeramie D Watrous 1, Mohit Jain 1, Rob Knight 1, Kenneth Schechtman 1, Bruce W Patterson 1, Samuel Klein 1 Main idea: In this study involving patients with obesity and […]
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Effect of Hemoglobin A1c Reduction or Weight Reduction on Blood Pressure in Glucagon-Like Peptide-1 Receptor Agonist and Sodium-Glucose Cotransporter-2 Inhibitor Treatment in Type 2 Diabetes Mellitus: A Meta-Analysis
November 7, 2021
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Mengdie Hu 1, Xiaoling Cai 1, Wenjia Yang 1, Simin Zhang 1, Lin Nie 2, Linong Ji 1 Main idea: Treatment with GLP-1RA and SGLT2i led to significant reductions in BP in patients with type 2 diabetes mellitus. Weight reduction was significantly and independently associated with BP reductions in GLP-1RA treatment and SGLT2i treatment. Abstract […]
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Impact of a Ketogenic Diet on Metabolic Parameters in Patients with Obesity or Overweight and with or without Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials
November 7, 2021
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Yeo Jin Choi 1, Sang-Min Jeon 2 3, Sooyoung Shin 2 3 Main idea: The study findings confirmed that ketogenic diets were more effective in improving metabolic parameters associated with glycemic, weight, and lipid controls in patients with overweight or obesity, especially those with preexisting diabetes, as compared to low-fat diets. Abstract The aim of […]
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Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial
November 7, 2021
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Gary Wittert 1, Karen Bracken 2, Kristy P Robledo 2, Mathis Grossmann 3, Bu B Yeap 4, David J Handelsman 5, Bronwyn Stuckey 6, Ann Conway 5, Warrick Inder 7, Robert McLachlan 8, Carolyn Allan 8, David Jesudason 9, Mark Ng Tang Fui 3, Wendy Hague 2, Alicia Jenkins 2, Mark Daniel 10, Val Gebski […]
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Effects of exercise, cognitive, and dual-task interventions on cognition in type 2 diabetes mellitus: A systematic review and meta-analysis
November 7, 2021
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Samuel Cooke 1, Kyla Pennington 2, Arwel Jones 1, Chris Bridle 3, Mark F Smith 4, Ffion Main idea: Meta-analyses of exercise trials identified a small effect size (0.31), which whilst not significant warrants further investigation. Abstract Introduction: Previous evidence has shown significant effects of exercise, cognitive and dual-task training for improving cognition in healthy […]
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Effects of Novel Dual GIP and GLP-1 Receptor Agonist Tirzepatide on Biomarkers of Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes
November 7, 2021
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Mark L Hartman 1, Arun J Sanyal 2, Rohit Loomba 3 4, Jonathan M Wilson 5, Amir Nikooienejad 5, Ross Bray 5, Chrisanthi A Karanikas 5, Kevin L Duffin 5, Deborah A Robins 5, Axel Haupt 5 Main idea: In post hoc analyses, higher tirzepatide doses significantly decreased NASH-related biomarkers and increased adiponectin in patients […]
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The Long-term Effects of Metformin on Patients With Type 2 Diabetic Kidney Disease
November 7, 2021
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Soie Kwon 1 2, Yong Chul Kim 1, Jae Yoon Park 3, Jeonghwan Lee 4, Jung Nam An 5, Clara Tammy Kim 6, Sohee Oh 7, Seokwoo Park 8 9, Dong Ki Kim 1 9, Yun Kyu Oh 2 9, Yon Su Kim 1, Chun Soo Lim 2 9, Jung Pyo Lee 4 9 Main […]
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Low-carbohydrate diets and type 2 diabetes treatment: a meta-analysis of randomized controlled trials
November 7, 2021
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G A Silverii 1, L Botarelli 2, I Dicembrini 2, V Girolamo 2, F Santagiuliana 3, M Monami 3, E Mannucci 2 Main idea: LC diets may produce small short-term improvements in HbA1c and weight, which are not maintained in the long term. Data on their renal safety are insufficient. Abstract Aim: To assess whether […]
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Effects of canagliflozin on anaemia in patients with type 2 diabetes and chronic kidney disease: a post-hoc analysis from the CREDENCE trial
November 7, 2021
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Megumi Oshima 1, Brendon L Neuen 2, Meg J Jardine 3, George Bakris 4, Robert Edwards 5, Adeera Levin 6, Kenneth W Mahaffey 7, Bruce Neal 8, Carol Pollock 9, Norman Rosenthal 5, Takashi Wada 10, David C Wheeler 11, Vlado Perkovic 12, Hiddo J L Heerspink 13 Main idea: These data suggest that canagliflozin […]
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