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Science Diabetes ulcers treatment

Effects of advanced glycation end products on neutrophil migration and aggregation in diabetic wounds
November 7, 2021
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Abstract Increased accumulation of advanced glycation end products (AGEs) in diabetic skin is closely related to delayed wound healing. Studies have shown that the concentration of AGEs is elevated in the skin tissues and not subcutaneous tissues in refractory diabetic wounds, which suggests there may be a causal relationship between the two. In the present […]
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Chronic pain with neuropathic characteristics after surgery for major trauma to the lower limb: prevalence, predictors, and association with pain severity, disability, and quality of life in the UK WHiST trial
November 7, 2021
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Abstract The aim of the study wasto identify the prevalence of neuropathic pain after lower limb fracture surgery, assess associations with pain severity, quality of life and disability, and determine baseline predictors of chronic neuropathic pain at three and at six months post-injury. The trial recruited 1,547 participants from 24 trauma centres. Neuropathic pain was […]
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Glycation by glyoxal leads to profound changes in the behavior of dermal fibroblasts
November 7, 2021
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Abstract Diabetes is a worldwide health problem that is associated with severe complications. Advanced Glycation End products (AGEs) such as Nε-(carboxymethyl)lysine, which result from chronic hyperglycemia, accumulate in the skin of patients with diabetes. The effect of AGEs on fibroblast functionality and their impact on wound healing are still poorly understood. The aim of the […]
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High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain
November 7, 2021
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Abstract The aim of the study was to evaluate whether, in subjects receiving haemodialysis (HD), the presence of diabetic foot syndrome (DFS) was associated with increased mortality compared with subjects with diabetes mellitus (DM) without DFS and with non-diabetic subjects. Retrospective, observational study in 220 subjects followed for six years. We calculated and compared the […]
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The Degree of Blood Supply and Infection Control Needed to Treat Diabetic Chronic Limb-Threatening Ischemia with Forefoot Osteomyelitis
November 7, 2021
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Abstract Background: Diabetic foot ulcers combined with ischemia and infection can be difficult to treat. Few studies have quantified the level of blood supply and infection control required to treat such complex diabetic foot ulcers. We aimed to propose an index for ischemia and infection control in diabetic chronic limb-threatening ischemia (CLTI) with forefoot osteomyelitis. […]
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Can Thermal Imaging Technique be Used to Predict the Healing Status of a Venous Leg Ulcer?
November 7, 2021
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Abstract Venous leg ulcers (VLUs) are the most common chronic wound types in older populations, with many wounds not healing in the normal trajectory. Many older people with wounds are treated in their homes, currently assessed by monitoring the wound area over weeks to ascertain the potential for healing. A noncontact method using thermal imaging […]
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Different therapeutic effects between diabetic and non-diabetic adipose stem cells in diabetic wound healing
November 7, 2021
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Abstract This study aimed to investigate how adipose tissue-derived stem cells (ASCs) from diabetic and from non-diabetic rats affect wound healing in different microenvironments. Adipose-derived stem cells (ASCs) are mesenchymal stem cells (MSCs) that are obtained from abundant adipose tissue, adherent on plastic culture flasks, can be expanded in vitro, and have the capacity to […]
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Network Pharmacology Analysis of ZiShenWan for Diabetic Nephropathy and Experimental Verification of Its Anti-Inflammatory Mechanism
November 7, 2021
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Abstract Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD). The inflammatory response plays a critical role in Diabetic nephropathy. ZiShenWan (ZSW) is a classical Chinese medicinal formula with remarkable clinical therapeutic effects on Diabetic nephropathy, but its pharmacological action mechanisms remain unclear. In this study, a network pharmacology approach was applied […]
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