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Science Irritable bowel syndrome (IBS)

Effects of treatment with eluxadoline on abdominal pain in patients with IBS-D: Additional post hoc analyses of Phase 3 trials
November 4, 2021
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Main idea: Despite small effect sizes, eluxadoline demonstrated consistent and sustained improvement in WAP compared to placebo across a range of prospective and post hoc analyses. Assessing WAP response across a range of measures is important for fully understanding a treatment’s efficacy. Abstract Recurring abdominal pain is a characteristic and often unpredictable and debilitating symptom […]
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The association between irritable bowel syndrome and osteoporosis: a systematic review and meta-analysis
November 4, 2021
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Main idea: A significantly increased risk of osteoporosis among IBS patients was observed in this study. Early intervention to prevent the development of osteoporosis, such as weight-bearing exercise, adequate intake of vitamin D and calcium, and early screening for osteoporosis, may be beneficial for these patients, although further studies are still required to confirm the […]
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A randomized clinical trial of mindfulness-based cognitive therapy for women with irritable bowel syndrome-Effects and mechanisms
November 7, 2021
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Main idea: MBCT-IBS has the potential to reduce IBS symptoms and increase the quality of life. MBCT-IBS may exert its effect on IBS symptoms via reducing maladaptive illness conditions and activating changes in self-processing (reducing biases in self-referent processing of illness and health and increasing non-judgmental awareness). Abstract Irritable bowel syndrome (IBS) is a chronic […]
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Brief Behavioral Therapy for Insomnia in Patients with Irritable Bowel Syndrome: A Pilot Study
November 7, 2021
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Main idea: This pilot study demonstrates the feasibility/acceptability of brief behavioral therapy for patients with IBS and poor sleep. Additionally, this study provides preliminary evidence to suggest that treatment of sleep difficulties in patients with IBS may improve IBS symptom outcomes. Abstract Up to 60% of patients with irritable bowel syndrome (IBS) report fatigue and […]
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Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) for the treatment of irritable bowel syndrome: a multi-center randomized double-blind placebo-controlled clinical trial
November 7, 2021
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Main idea: This study shows that B bifidum HI-MIMBb75 substantially alleviates IBS and its symptoms in a real-life setting. These results indicate that specific beneficial bacterial effects are mediated independently of cell viability. Abstract Bifidobacterium bifidum MIMBb75 is one of a few probiotic strains that have been shown to be effective in the treatment of […]
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Efficacy of Lactobacillus paracasei HA-196 and Bifidobacterium longum R0175 in Alleviating Symptoms of Irritable Bowel Syndrome (IBS): A Randomized Placebo-Controlled Study
November 7, 2021
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Main idea: L. paracasei and B. longum may reduce GI symptom severity and improve the psychological well-being of individuals with certain IBS subtypes. Abstract Specific probiotic strains can alleviate the gastrointestinal (GI) symptoms and psychiatric comorbidities of irritable bowel syndrome (IBS). In this randomized double-blind placebo-controlled study the efficacy of Lactobacillus paracasei HA-196 (L. paracasei) […]
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Randomized clinical trial: faecal microbiota transplantation versus autologous placebo administered via colonoscopy in irritable bowel syndrome
November 7, 2021
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Main idea: FMT provided only transient relief of symptoms, although it induced a sustained alteration in the microbiota of IBS patients. Therefore, FMT delivered by a single infusion via colonoscopy can not be recommended as a treatment for IBS in clinical practice. Abstract Irritable bowel syndrome (IBS) has been associated with microbial dysbiosis. The aim […]
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The efficacy and safety of probiotics for patients with constipation-predominant irritable bowel syndrome: A systematic review and meta-analysis based on seventeen randomized controlled trials
November 7, 2021
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Main idea: Generally, probiotics may be safe and may improve whole gut transit time, stool frequency, and stool consistency. However, adequately powered RCTs are required to better determine the species or strains, doses, and duration of use of probiotics that are most efficacious. Further research and evidence are required before probiotics are adopted as one […]
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Randomized clinical trial: linaclotide vs placebo-a study of bi-directional gut and brain axis
November 7, 2021
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Main idea: Linaclotide prolongs afferent gut-brain signaling from baseline but both afferent and efferent signaling were unaffected compared to placebo. Linaclotide significantly improves rectal hypersensitivity, IBS-C symptoms, and QOL compared to placebo. Abstract Linaclotide, a guanylate cyclase C agonist relieves irritable bowel syndrome with predominant constipation (IBS-C) symptoms. However, the pain-relieving properties are still unknown. […]
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β-Galactooligosaccharide in Conjunction With Low FODMAP Diet Improves Irritable Bowel Syndrome Symptoms but Reduces Fecal Bifidobacteria
November 7, 2021
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Main idea: The LFD combined with B-GOS prebiotic produced a greater symptom response than the sham diet plus placebo, but the addition of 1.4 g/d B-GOS did not prevent the reduction of bifidobacteria. The LFD reduces fecal Actinobacteria and butyrate thus strict long-term use should not be advised. Abstract The low FODMAP diet (LFD) reduces […]
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