Science Irritable bowel syndrome (IBS)

Main idea: The study has demonstrated that consuming the skin of SunGold kiwifruit might have beneficial effects on gastrointestinal health that are not produced by consuming the flesh alone. Abstract Irritable bowel syndrome (IBS) is a common gastrointestinal disorder that results in constipation (IBS-C) or diarrhea with abdominal pain, flatulence, nausea, and bloating. Kiwifruit (Actinidia […]

Main idea: Acupuncture may be more effective than PEG 4000 or pinaverium bromide for the treatment of IBS with effects lasting up to 12 weeks. Abstract The objective of the study was to evaluate the effect and safety of acupuncture for the treatment of irritable bowel syndrome (IBS) through comparisons with those of polyethylene glycol […]

Abstract Agonists of 5-hydroxytryptamine 4 receptors are potential agents for irritable bowel syndrome with predominant constipation (IBS-C). However, only tegaserod has been approved for a very limited population in the US. The aim of the study was to evaluate the efficacy and safety of minesapride in patients with IBS-C. A greater percentage of minesapride 40 […]

Main idea: The multi-strain synbiotic preparation was associated with a significant improvement in symptoms in IBS-D patients and was well-tolerated. These results suggest that the use of synbiotics offers a benefit for IBS-D patients. Abstract The purpose of the randomized double-blind placebo-controlled trial was to assess the effectiveness of synbiotic preparation containing probiotic Lactobacillus rhamnosus […]

Abstract Previously, small studies have suggested that ondansetron has beneficial effects in diarrhea-predominant irritable bowel syndrome (IBS-D). This randomized, double-blind study evaluated the efficacy and safety of daily 12 mg RHB-102 an investigational bimodal release ondansetron tablet in IBS-D. Overall stool consistency response rates were 56.0% and 35.3% and similar among male and female patients. […]

Main idea: Herb-separated moxibustion at Jinsuo (GV 8)-eight-diagram points remarkably relieves gastrointestinal symptoms and improves the quality of life in patients of diarrhea-type irritable bowel syndrome of liver stagnation and spleen deficiency, and its clinical therapeutic effect is superior to oral administration of either pinaverium bromide tablets or tongxieyaofang. Abstract The objective of the study […]

Main idea: Plecanatide is a well-tolerated and effective treatment option for patients aged ≥65 years with CIC or IBS-C. Abstract Chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) are common functional gastrointestinal disorders. The prevalence of constipation-related issues tends to increase with age. This analysis pooled data from Phase III trials in […]

Main idea: The metagenomics analysis reveals shifts in the microbiome post-intervention that have been cross-validated with the literature as being associated with improvement of IBS symptoms. Abstract Irritable bowel syndrome (IBS) is the most prevalent functional gastrointestinal disorder worldwide, and the most common reason for referral to gastroenterology clinics. However, the pathophysiology is still not […]

Abstract Dietary fructans may worsen gastrointestinal symptoms in children with irritable bowel syndrome (IBS). The aim of the study was to determine whether gut microbiome composition and function are associated with childhood IBS fructan-induced symptoms. The faecal samples from 38 children aged 7-17 years were analyzed for fructan sensitivity. At baseline, 17 fructan-sensitive (vs 21 […]

Main idea: The results suggest that the partial hydrolyzation of milk proteins (mainly casein) reduces subjective symptoms to some extent in subjects with functional gastrointestinal disorders. The mechanism remains to be resolved. Abstract Unspecified gastrointestinal symptoms associated with milk consumption are common. In addition to lactose also other components of milk may be involved. The […]