Science Parkinson’s disease

Main idea: The study provides evidence that all three exercise programs (the effect of Lee Silverman Voice Treatment (LSVT) BIG, an intensified and personalized physiotherapy (INTENSIVE), and conventional physiotherapy (NORMAL)) are effective techniques to improve non-motor symptoms as well as motor function in Parkinson’s disease patients. Abstract  Parkinson’s disease (PD) patients experience disabling motor dysfunctions […]

Main idea: Uric acid concentration can be a marker for Parkinson’s disease detection. The patients with Parkinson’s disease have a significantly lower concentration of uric acid. Abstract Previous studies have highlighted serum uric acid as a putative idiopathic Parkinson’s disease (iPD) biomarker. But a longitudinal comparison between LRRK2 + PD and healthy controls (HC) has […]

Main idea: one of the well-known cognitive tests (clock drawing) can be used as a diagnostic tool to distinguish Parkinson’s disease type. Abstract  A companion paper reports on the neuroimaging and neuropsychological profiles of statistically determined idiopathic non-dementia Parkinson’s disease (PD) The current investigation sought to further examine subtle behavioral clock drawing differences within the […]

Main idea: Multistrain probiotics treatment was effective for constipation in Parkinson’s disease patients. Abstract  To determine whether probiotics are effective for constipation, a common and often difficult-to-treat problem, in Parkinson’s disease (PD). In this double-blind, randomized, placebo-controlled, single-center trial, 280 patients with PD were screened. 72 eligible patients were block-randomized to receive either multistrain probiotics […]

Main idea: It is now clear that α-synuclein-associated inflammation contributes to the pathophysiology of PD  but research on whether or how α-synuclein modulates the function of macrophages in the brain has been mostly focused on microglia. As a result, our knowledge of the role of α-synuclein in other brain resident macrophages such as BAMs or […]

Main idea: A new therapeutic method based on gene therapy found for Parkinson’s disease. It is based on short samples of DNA that encodes α-synuclein, one of the crucial regulators of Parkinson’s disease progression. Abstract  Parkinson’s disease (PD) is a prevalent neurodegenerative disease with no approved disease-modifying therapies. Multiplications, mutations in the SNCA gene either […]

Main idea: A Rheumatoid arthritis diagnosis is significantly associated with a lower incidence of subsequent PD diagnosis. We propose that common anti-inflammatory treatments used in RA might protect against the later development of PD [35]. This hypothesis can be tested by examining PD risk imposed by the use of anti-inflammatory drugs in conditions other than […]

Main idea: a new model of the PD pathogenesis is proposed that takes into account the origin site of the initiating α-synuclein pathology and the important role played by the highly lateralized connectivity of the human brain. The SOC model may have greater explanatory power than previously proposed models as it is readily compatible with […]

Main idea: Digital technology helps to shift healthcare from reactive to preventive and predictive care. Within this shift, there is a growing demand to make sleep assessment possible using home-based systems. Recent developments offer new and exciting opportunities, but there is still a long process to ensure clinical use. The study proves that sleep cycles […]

Main idea: These results suggest that motor and non-motor symptoms of PD are associated in patients, and, in particular, that postural sway shows potential as a possible measure of underlying disease status in PD, either alone or in combination with other measures. Abstract  The severity of Parkinson’s disease (PD) is difficult to assess owing to […]