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Science Gout

Sex Differences in the Clinical Profile Among Patients With Gout: Cross-sectional Analyses of an Observational Study
November 7, 2021
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Ritch te Kampe, Matthijs Janssen, Caroline van Durme, Tim L. Jansen and Annelies Boonen Main idea: This study revealed that sex differences in comorbidities among those with gout onset beyond the age of female menopause were strongly attenuated and fully explained by lifestyle. Abstract Objective. Research findings in gout result predominantly from studies about men […]
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Role of Vitamin C in Prophylaxis and Treatment of Gout
November 7, 2021
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by Olga Brzezińska 1,*OrcID,Filip Styrzyński 1OrcID,Joanna Makowska 1 andKonrad Walczak 2 Main idea: results of the studies do not clearly define the benefits of a high daily intake of vitamin C in preventing the development and recurrence of gout Abstract Gout, known as “the disease of the kings”, is the most frequent type of arthritis. […]
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Beyond Medical Treatment: Surgical Treatment of Gout
November 7, 2021
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Jonathan Carcione, Shari Bodofsky, Brian LaMoreaux & Naomi Schlesinger Main idea: Most patients were not taking ULT at the time of surgery, leading to hyperuricemia. This can result in tophi reformation post-surgery. The role of surgery should be a last-line treatment Abstract Purpose of Review Medical treatment with urate-lowering therapy (ULT) is efficacious. A recent […]
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Elevated Uric Acid Prevalence and Clinical Outcomes in Patients with Heart Failure with Preserved Ejection Fraction: Insights from RELAX
November 7, 2021
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Anthony P Carnicelli 1, Jie-Lena Sun 2, Brooke Alhanti 2, Magnus Bjursell 3, Shira Perl 4, Barbara Lytle 2, Matthew T Roe 5, Robert J Mentz 5 Main idea: Serum uric acid is an important marker of comorbidities and functional status in patients with heart failure with preserved ejection fraction. Clinical trials of serum uric […]
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Effects of Aster glehni Extract on Serum Uric Acid in Subjects with Mild
November 7, 2021
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Hyperuricemia: A Randomized, Placebo-Controlled Trial Soyeon Lee 1 2, Eun Hye Han 2 3, Sang Ho Lee 2 3, Mi Kyung Lim 4, Chang-O Kim 5, Seongman Kang 1 Main idea: Aster glehni extracts supplementation for 12 weeks did not show significant benefits for reducing serum uric acid concentrations in subjects with mild hyperuricemia. Abstract […]
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Randomized, Open-Label, Cross-Over Comparison of the Effects of Benzbromarone and Febuxostat on Endothelial Function in Patients with Hyperuricemia
November 7, 2021
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Tomoo Nakata 1 2, Satoshi Ikeda 1, Seiji Koga 1, Tsuyoshi Yonekura 1, Akira Tsuneto 1, Yoshiyuki Doi 1, Satoki Fukae 1, Takako Minami 1, Hiroaki Kawano 1, Koji Maemura 1 Main idea: Benzbromarone has increased adiponectin besides reducing uric acid levels, and thus, this might confer more benefits on endothelial function than febuxostat in […]
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Febuxostat Attenuates the Induction of Vascular Cell Adhesion Protein 1 by TNF-α in Human Umbilical Vein Endothelial Cells
November 7, 2021
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Yasuhiro Suzuki 1 2, Mari Deguchi 1, Airi Furuya 1, Sayuki Kato 1, Shoichiro Ohta 3 Main idea: The effect of febuxostat treatment on cardiovascular events may be associated with protection against the infiltration of lymphocytes or monocytes through VCAM-1 induction in inflamed endothelial cells such as arterial sclerosis. Abstract In a randomized trial, higher […]
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Efficacy of xanthine oxidase inhibitor for chronic kidney disease patients with hyperuricemia
November 7, 2021
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Hiroshi Matsuo 1, Eiji Ishikawa 2, Hirofumi Machida 3, Yasuhide Mizutani 4, Akiko Tanoue 1 5, Takahiro Ohnishi 6, Tomohiro Murata 7, Shinya Okamoto 1, Toru Ogura 8, Yuki Nishimura 8, Hiroo Ito 9, Masashi Yasutomi 10, Kan Katayama 7, Shinsuke Nomura 1, Masaaki Ito 7 Main idea: In this study, xanthine oxidase inhibitors did […]
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Asymptomatic hyperuricemia and incident congestive heart failure in elderly patients without comorbidities
November 7, 2021
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Xianfeng Wu 1, Guihua Jian 1, Yuezhong Tang 2, Huan Cheng 2, Niansong Wang 3, Junnan Wu 4 Main idea: Asymptomatic hyperuricemia was a valuable biomarker for predicting the development of incident CHF (chronic heart failure) in elderly patients without comorbidities. Abstract Background and aims: Although hyperuricemia is associated with congestive heart failure (CHF), hyperuricemic […]
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Changeover Trial of Febuxostat and Topiroxostat for Hyperuricemia with Cardiovascular Disease: Sub-Analysis for Chronic Kidney Disease
November 7, 2021
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Akira Sezai 1, Satoshi Unosawa 1, Makoto Taoka 1, Shunji Osaka 1, Hisakuni Sekino 2, Masashi Tanaka 1 Main idea: Febuxostat had stronger renoprotective and antioxidant effects than topiroxostat in patients with hyperuricemia and chronic kidney disease. Abstract Background: The TROFEO trial demonstrated that febuxostat causes a greater and more rapid reduction of serum uric […]
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