Science Gout

Ritch te Kampe, Matthijs Janssen, Caroline van Durme, Tim L. Jansen and Annelies Boonen Main idea: This study revealed that sex differences in comorbidities among those with gout onset beyond the age of female menopause were strongly attenuated and fully explained by lifestyle. Abstract Objective. Research findings in gout result predominantly from studies about men […]

by Olga Brzezińska 1,*OrcID,Filip Styrzyński 1OrcID,Joanna Makowska 1 andKonrad Walczak 2 Main idea: results of the studies do not clearly define the benefits of a high daily intake of vitamin C in preventing the development and recurrence of gout Abstract Gout, known as “the disease of the kings”, is the most frequent type of arthritis. […]

Jonathan Carcione, Shari Bodofsky, Brian LaMoreaux & Naomi Schlesinger Main idea: Most patients were not taking ULT at the time of surgery, leading to hyperuricemia. This can result in tophi reformation post-surgery. The role of surgery should be a last-line treatment Abstract Purpose of Review Medical treatment with urate-lowering therapy (ULT) is efficacious. A recent […]

Anthony P Carnicelli 1, Jie-Lena Sun 2, Brooke Alhanti 2, Magnus Bjursell 3, Shira Perl 4, Barbara Lytle 2, Matthew T Roe 5, Robert J Mentz 5 Main idea: Serum uric acid is an important marker of comorbidities and functional status in patients with heart failure with preserved ejection fraction. Clinical trials of serum uric […]

Hyperuricemia: A Randomized, Placebo-Controlled Trial Soyeon Lee 1 2, Eun Hye Han 2 3, Sang Ho Lee 2 3, Mi Kyung Lim 4, Chang-O Kim 5, Seongman Kang 1 Main idea: Aster glehni extracts supplementation for 12 weeks did not show significant benefits for reducing serum uric acid concentrations in subjects with mild hyperuricemia. Abstract […]

Tomoo Nakata 1 2, Satoshi Ikeda 1, Seiji Koga 1, Tsuyoshi Yonekura 1, Akira Tsuneto 1, Yoshiyuki Doi 1, Satoki Fukae 1, Takako Minami 1, Hiroaki Kawano 1, Koji Maemura 1 Main idea: Benzbromarone has increased adiponectin besides reducing uric acid levels, and thus, this might confer more benefits on endothelial function than febuxostat in […]

Yasuhiro Suzuki 1 2, Mari Deguchi 1, Airi Furuya 1, Sayuki Kato 1, Shoichiro Ohta 3 Main idea: The effect of febuxostat treatment on cardiovascular events may be associated with protection against the infiltration of lymphocytes or monocytes through VCAM-1 induction in inflamed endothelial cells such as arterial sclerosis. Abstract In a randomized trial, higher […]

Hiroshi Matsuo 1, Eiji Ishikawa 2, Hirofumi Machida 3, Yasuhide Mizutani 4, Akiko Tanoue 1 5, Takahiro Ohnishi 6, Tomohiro Murata 7, Shinya Okamoto 1, Toru Ogura 8, Yuki Nishimura 8, Hiroo Ito 9, Masashi Yasutomi 10, Kan Katayama 7, Shinsuke Nomura 1, Masaaki Ito 7 Main idea: In this study, xanthine oxidase inhibitors did […]

Xianfeng Wu 1, Guihua Jian 1, Yuezhong Tang 2, Huan Cheng 2, Niansong Wang 3, Junnan Wu 4 Main idea: Asymptomatic hyperuricemia was a valuable biomarker for predicting the development of incident CHF (chronic heart failure) in elderly patients without comorbidities. Abstract Background and aims: Although hyperuricemia is associated with congestive heart failure (CHF), hyperuricemic […]

Akira Sezai 1, Satoshi Unosawa 1, Makoto Taoka 1, Shunji Osaka 1, Hisakuni Sekino 2, Masashi Tanaka 1 Main idea: Febuxostat had stronger renoprotective and antioxidant effects than topiroxostat in patients with hyperuricemia and chronic kidney disease. Abstract Background: The TROFEO trial demonstrated that febuxostat causes a greater and more rapid reduction of serum uric […]