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Science Gout

Ultrasound shows rapid reduction of crystal depositions during a treat-to-target approach in gout patients: 12-month results from the NOR-Gout study
November 7, 2021
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Hilde Berner Hammer 1 2, Lars Karoliussen 3, Lene Terslev 4, Espen A Haavardsholm 3, Tore K Kvien 3 2, Till Uhlig 3 2 Main idea: The ultrasound scoring system for crystal depositions was sensitive to change and showed that a treat-to-target approach with urate-lowering treatment resulted in significant reductions of all the depositions, most […]
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Lack of effect of tart cherry concentrate dose on serum urate in people with gout
November 7, 2021
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Lisa K Stamp 1, Peter Chapman 2, Christopher Frampton 1, Stephen B Duffull 3, Jill Drake 1, Yuqing Zhang 4, Tuhina Neogi 4 Main idea: Tart cherry concentrate had no effect on SU or urine urate excretion. Abstract Objectives: Cherry concentrate has been suggested to reduce serum urate (SU) and gout flares. The aims of […]
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Effects of Allopurinol on the Progression of Chronic Kidney Disease
November 7, 2021
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Sunil V Badve 1, Elaine M Pascoe 1, Anushree Tiku 1, Neil Boudville 1, Fiona G Brown 1, Alan Cass 1, Philip Clarke 1, Nicola Dalbeth 1, Richard O Day 1, Janak R de Zoysa 1, Bettina Douglas 1, Randall Faull 1, David C Harris 1, Carmel M Hawley 1, Graham R D Jones 1, […]
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Open-label randomized pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care
November 7, 2021
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Edward Roddy 1 2, Kris Clarkson 3 4, Milica Blagojevic-Bucknall 3 4, Rajnikant Mehta 5, Raymond Oppong 6, Anthony Avery 7, Elaine M Hay 3, Carl Heneghan 8, Liz Hartshorne 3 4, Julie Hooper 9, Gemma Hughes 3 4, Sue Jowett 3 6, Martyn Lewis 3 4, Paul Little 9, Karen McCartney 7, Kamal R […]
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Gout and Progression of Aortic Stenosis
November 7, 2021
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Andrew Adelsheimer 1, Binita Shah 2, Alana Choy-Shan 3, Craig T Tenner 4, Jeffrey D Lorin 3, Nathaniel R Smilowitz 3, V Courtney Pike 5, Michael H Pillinger 5, Robert Donnino 3 Main idea: Progression to severe aortic stenosis was more frequent in patients with gout compared with those without gout, supporting the hypothesis that […]
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Long-term cardiovascular safety of febuxostat compared with allopurinol in patients with gout (FAST): a multicentre, prospective, randomized, open-label, non-inferiority trial
November 7, 2021
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Isla S Mackenzie 1, Ian Ford 2, George Nuki 3, Jesper Hallas 4, Christopher J Hawkey 5, John Webster 6, Stuart H Ralston 7, Matthew Walters 8, Michele Robertson 2, Raffaele De Caterina 9, Evelyn Findlay 1, Fernando Perez-Ruiz 10, John J V McMurray 8, Thomas M MacDonald 11, FAST Study Group Main idea: Febuxostat […]
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Estimation of Primary Prevention of Gout in Men Through Modification of Obesity and Other Key Lifestyle Factors
November 7, 2021
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Natalie McCormick 1 2 3 4, Sharan K Rai 4 5, Na Lu 4 6, Chio Yokose 1 2 3, Gary C Curhan 6 7, Hyon K Choi Main idea: The findings of this cohort study suggest that addressing excess adiposity and other key modifiable factors has the potential to prevent the majority of incident […]
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Allopurinol use and type 2 diabetes incidence among patients with gout: A VA retrospective cohort study
November 7, 2021
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Anastasia Slobodnick 1 2, Michael Toprover 1 2, Jeffrey Greenberg 2, Daria B Crittenden 2, Virginia C Pike 1 2, Yingzhi Qian 3, Hua Zhong 3, Michael H Pillinger 1 2 Main idea: In this study, allopurinol use was not associated with decreased diabetes incidence. Abstract To assess the impact of allopurinol on diabetes in […]
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